Expression of the CXCL12/SDF-1 Chemokine Receptor CXCR7 in Human Brain Tumours

Tang, Tian; Xia, Qing-Jie; Chen, Jian-Bin; Xi, Ming-Rong; Lei, Ding

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자료유형: 학술저널

저자정보: Tang, Tian (West China Medical School, Sichuan University) Xia, Qing-Jie (West China Laboratory of Molecular Genetics, Sichuan University) Chen, Jian-Bin (Department Of Neurosurgery, West China Hospital of Sichuan University) Xi, Ming-Rong (Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University) Lei, Ding (Department Of Neurosurgery, West China Hospital of Sichuan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제10호

발행연도: 2012.1

수록면: 5,281 - 5,286 (6page)

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Purpose: Receptor 7 (CXCR7) has recently been characterized as a novel receptor for CXCL12/SDF-1 (stromal cell derived factor-1). Given the demonstrated importance of CXCL12/SDF-1 in angiogenesis and tumour metastasis, we hypothesized that CXCR7 may also play a role in tumour pathogenesis. Located in the limited space of the intracranial cavity, any brain tumours can be inherently serious and life-threatening. However, the expression of CXCR7 in pituitary adenoma, neurilemmoma or hemangioblastoma remains to be elucidated. Therefore, we aimed to determine the potential contribution of CXCR7 in the development of brain tumours. Methods: In this study we examined and quantified the mRNA expression of CXCR7 in four different human brain tumours - 27 patients with neurilemmoma (8 patients), pituitary adenoma (7 patients), hemangioblastoma (6 patients), or meningioma (6 patients) undergoing surgical resection in the West China Hospital of Sichuan University. There were 15 females and 12 males aged from 28 to 70 years old. Total RNA was isolated and mRNA was measured by quantitative real-time RT-PCR. One-way analysis of variance (ANOVA) was performed using SPSS 11.0 statistical software to compare the mRNA levels of CXCR7 among four groups. Results: We found that CXCR7 mRNA was detected in all tumour samples. Quantitative results showed that the levels of CXCR7 mRNA in brain tissues from patients with neurilemmoma or meningioma were significantly higher than those with pituitary adenoma or hemangioblastoma. Conclusions: The results suggest that the CXCR7 may play a role in progression, metastasis and angiogenesis of brain tumours.

#CXCR7 #chemokine receptors #neurilemmoma #pituitary adenoma #hemangioblastoma

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Tang, Tian

소속기관 West China Medical School, Department of Gynecology and Obstetrics, West China Women's and Children'