지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 45 - 51 (7page)
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Background and Objectives: Follicular tumors can present a difficult diagnostic challenge for cytological evaluation and ultrasound findings. Therefore, new methods which could help distinguish follicular adenoma from follicular carcinoma simply and accurately are greatly desired. This study investigated the usefulness of immnunohistochemical expression of CXC chemokine receptor 4 (CXCR4) and galectin-3 as marker of differentiated thyroid carcinomas. Materials and Methods: Expression of CXCR4 and galectin-3 were examined immunohistochemically in the 60 paraffin embedded tissues which were already diagnosed as follicular adenoma (n=20), follicullar carcinoma (n=20), and papillary carcinoma (n=20) of thyroid. Results: Galatin-3 was expressed significantly high in follicular carcinoma than follicular adenoma (p=0.022). CXCR4 was also expressed significantly high in follicular carcinoma than follicular adenoma (p=0.027). The sensitivity of CXCR4 and galectin-3 was 70% and 80% and specificity, 65% and 60% for differential diagnosis of follicular tumors.
Conclusion: An immunohistochemical panel, including galatin-3 and CXCR4, could be useful in the differential diagnosis between follicular adenoma from follicular carcinoma.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Amrikachi M / 2001 / Accuracy of fine-needle aspiration of thyroid / Arch Pathol Lab Med 125 (4) : 484 ~ 488
Bartolazzi A / 2001 / Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions / Lancet 357 (9269) : 1644 ~ 1650
Choufani G / 1999 / The levels of expression of galectin-1, galectin-3, and the Thomsen-Friedenreich antigen and their binding sites decrease as clinical aggressiveness incr
Ezzat S / 1994 / Thyroid incidentalomas. Prevalence by palpation and ultrasonography / Arch Intern Med 154 (16) : 1838 ~ 1840
Fernandez PL / 1997 / Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue / J Pathol 181 (1) : 80 ~ 86
Bartolazzi A / 2001 / Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions / Lancet 357 (9269) : 1644 ~ 1650
Choufani G / 1999 / The levels of expression of galectin-1, galectin-3, and the Thomsen-Friedenreich antigen and their binding sites decrease as clinical aggressiveness incr
Ezzat S / 1994 / Thyroid incidentalomas. Prevalence by palpation and ultrasonography / Arch Intern Med 154 (16) : 1838 ~ 1840
Fernandez PL / 1997 / Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue / J Pathol 181 (1) : 80 ~ 86
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