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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제1호
- 발행연도
- 2018.1
- 수록면
- 9 - 13 (5page)
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Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Methods: Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009. Tissue microarray blocks were made using representative paraffin blocks of classical PTCs excluding follicular variants. Two pathologists graded the proportion and intensity of PD-L1 and PD-1 expression in both tumor and inflammatory cells. According to their proportions, positive PTC cells were scored as negative (0%), grade 1 (1%–50%), and grade 2 (51%–100%). Similarly, positive inflammatory cells were graded as negative (0%), grade 1 (1%–10%), and grade 2 (11%–20%). The intensity of each protein expression was simplified as positive or negative. Results: A statistically significant correlation exists between the proportions of PD-1 and PD-L1 expression both in papillary carcinoma (p = .001) and peritumoral lymphoid cells in the thyroid (p < .001). In addition, the proportion of PD-L1 expression in PTC cells was closely related to metastatic LNs (p = .036). Conclusions: PD-L1 is a valuable predictive marker for LN metastasis in PTC. Immunomodulating therapies that inhibit PD-L1 might be an option for patients with LN metastasis.
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참고문헌 (26)
참고문헌 신청
Herbst RS / 2016 / Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial / Lancet 387:1540~1550
Juarez-Salcedo LM / 2017 / The role of anti-PD-1 and anti-PD-L1 agents in the treatment of diffuse large B-cell lymphoma: The future is now / Crit Rev Oncol Hematol 113:52~62
Motoshima T / 2017 / PD-L1 expression in papillary renal cell carcinoma / BMC Urol 17:8
Fontugne J / 2017 / PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma / Oncotarget 8:24644~24651
Jiang Y / 2017 / Prognostic significance of tumor-infiltrating immune cells and PD-L1 expression in esophageal squamous cell carcinoma / Oncotarget 8:30175~30189
Juarez-Salcedo LM / 2017 / The role of anti-PD-1 and anti-PD-L1 agents in the treatment of diffuse large B-cell lymphoma: The future is now / Crit Rev Oncol Hematol 113:52~62
Motoshima T / 2017 / PD-L1 expression in papillary renal cell carcinoma / BMC Urol 17:8
Fontugne J / 2017 / PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma / Oncotarget 8:24644~24651
Jiang Y / 2017 / Prognostic significance of tumor-infiltrating immune cells and PD-L1 expression in esophageal squamous cell carcinoma / Oncotarget 8:30175~30189
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