Prognostic Value of Combined Programmed Cell Death 1 Ligand and p16 Expression Predicting Responsiveness to Radiotherapy in Patients with Oropharyngeal Squamous Cell Carcinoma

권민수; 김대환; 조기주; 김영철; 김진평; 정배권; 이종실; 서지현; 박정제

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자료유형: 학술저널

저자정보: 권민수 김대환 조기주 김영철 김진평 정배권 이종실 서지현 박정제

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제62권 제12호

발행연도: 2019.1

수록면: 712 - 719 (8page)

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Background and Objectives This study examined the expressions of p16 and the programmedcell death 1 ligand (PD-L1) in patients with oropharyngeal cancer (OPC) treated withradiotherapy (RT) to identify the correlation between p16 and PD-L1 expression, and to examinethe prognostic significance of these markers for OPC patients receiving RT. Subjects and Method Forty-eight OPC patients diagnosed and treated at a tertiary referralhospital were enrolled in this retrospective analysis. Patients were initially treated with RT orchemoradiotherapy (CRT) with curative intent and completed the planned schedule. Expressionof p16 and PD-L1 by primary tumors was evaluated by immunohistochemistry, and resultswere interpreted separately and dichotomized according to outcome analyses. Results Of the 48 patients, 25 (52.1%) expressed p16 and 15 (31.3%) expressed PD-L1. Expressionof these markers showed a mutual positive correlation (p=0.046). Positive PD-L1 expressionwas associated with poor complete remission (CR) rates after RT (p=0.040). Positivep16 expression was associated with better recurrence-free survival (RFS) (p=0.004) but notoverall survival (OS) (p=0.192). PD-L1 expression showed no independent association withsurvival (p>0.05); however, PD-L1 expression tended toward poorer RFS, even in p16-positiveindividuals. Conclusion There was a positive correlation between the expression of p16 and PD-L1 inOPCs. PD-L1 expression was associated with poorer CR rates after RT or CRT. PD-L1 alonedid not show an association with RFS or OS, but when combined with p16, it tended towardpoorer RFS, even in p16-positive cases.

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참고문헌 신청

Ang KK / 2012 / Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma / Semin Radiat Oncol 22(2):128~142

Sano D / 2016 / The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma / Int J Clin Oncol 21(5):819~826

Ang KK / 2010 / Human papillomavirus and survival of patients with oropharyngeal cancer / N Engl J Med 363(1):24~35

Lassen P / 2014 / Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer / Radiother Oncol 113(3):310~316

Galloway TJ / 2016 / Prognostic value of p16 status on the development of a complete response in involved oropharynx cancer neck nodes after cisplatin-based chemoradiation : A secondary analysis of NRG oncology RTOG 0129 / Int J Radiat Oncol Biol Phys 96(2):362~371

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