지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims : Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with a specific clinical and molecular presentation. Treatment of acute promyelocytic leukemia with all-trans retinoic acid or arsenic trioxide in association with anthracyclin has improved outcomes in this disease. We report the results of all-trans retinoic acid and arsenic trioxide-based treatment regimens in acute promyelocytic leukemia patients diagnosed in a single center.
Methods : Thirty-seven treatment events in 26 patients with acute promyelocytic leukemia were retrospectively reviewed.
Results : Complete remission was achieved in 29 (78.4%) of 37 treatment events. One-year overall survival rate and 1-year event-free survival rate were 74.3% and 66.3%, respectively. Among 16 patients treated with an arsenic trioxide-based regimen, 14 patients (87.5%) achieved complete remission. The 1-year overall survival rate and 1-year event-free survival rate were 78.4% and 69.6%, respectively.
Conclusions : The short-term use of arsenic trioxide for salvage treatment of acute promyelocytic leukemia seems to be efficacious and could be a bridge to intensive chemotherapy or stem cell transplantation in terms of minimizing the risk of severe disseminated intravascular coagulation. (Korean J Med 74:596-604, 2008)
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참고문헌 (23)
참고문헌 신청
Avvisati G / 1996 / AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia / Blood 88 : 1390 ~ 1398
Chen Z / 2001 / Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies / Semin Hematol 38 : 26 ~ 36
Degos L / 2001 / All trans retinoic acid in acute promyelocytic leukemia / Oncogene 20 : 7140 ~ 7145
Ding W / 1998 / Leukemic cellular retinoic acid resistance and missense mutations in the PML/RARα fusion gene after relapse of acute promyelocytic leukemia from treatment w
Estey EH / 2004 / Use of all-trans retinoic acid (ATRA) + arsenic trioxide (ATO) to eliminate or minimize use of chemotherapy in untreated acute promyelocytic leukemia (APL)
Chen Z / 2001 / Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies / Semin Hematol 38 : 26 ~ 36
Degos L / 2001 / All trans retinoic acid in acute promyelocytic leukemia / Oncogene 20 : 7140 ~ 7145
Ding W / 1998 / Leukemic cellular retinoic acid resistance and missense mutations in the PML/RARα fusion gene after relapse of acute promyelocytic leukemia from treatment w
Estey EH / 2004 / Use of all-trans retinoic acid (ATRA) + arsenic trioxide (ATO) to eliminate or minimize use of chemotherapy in untreated acute promyelocytic leukemia (APL)
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