지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 227 - 231 (5page)
이용수
초록· 키워드
오류제보하기
Acute promyelocytic leukemia (APL) is considered as a curative disease after combined chemotherapy based on all-trans retinoic acid (ATRA) and anthracycline. However, as long-term survivors continue to increase, reports on sporadic cases of therapy-related myeloid neoplasm (t-MN) after successful APL treatment are also increasing. Recently, we have experienced one patient who developed t-MN 7 yr after APL diagnosis. Even though he had not been exposed to alkylating agents at all, he showed alkylating agents-associated features such as long latency period ( >5 yr),first presentation as myelodysplatic phase (multilineage dysplasia with increased blasts), and complex karyotype including monosomy 5 and 7. He received only supportive care and expired 3 months after the diagnosis of t-MN (6 months of survival after the onset of cytopenias). t-MN after complete remission of APL is a rare but fatal complication, and patients with complex karyotypes show ominous prognosis in particular. For the early diagnosis of t-MN, long-term and close monitoring of the patient is needed. One should suspect this late complication whenever any unknown cytopenia develops, and should perform bone marrow biopsy and cytogenetic analysis.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Athanasiadou A / 2002 / Therapy-related myelodysplastic syndrome with monosomy 5 and 7 following successful therapy for acute promyelocytic leukemia with anthracyclines / Le
Au WY / 2001 / Therapy-related myelodysplastic syndrome after eradication of acute promyelocytic leukemia: cytogenetic and molecular features / Hum Pathol 32 : 126 ~ 129
Drake M / 2003 / Early second leukaemia in a patient with successfully treated acute promyelocytic leukaemia / Leuk Lymphoma 44 : 895 ~ 896
Felice MS / 1999 / Acute trilineage leukemia with monosomy of chromosome 7 following an acute promyelocytic leukemia / Leuk Lymphoma 34 : 409 ~ 413
Garcia-Manero G / 2002 / Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL) / Leukemia 16 : 1888 ~
Au WY / 2001 / Therapy-related myelodysplastic syndrome after eradication of acute promyelocytic leukemia: cytogenetic and molecular features / Hum Pathol 32 : 126 ~ 129
Drake M / 2003 / Early second leukaemia in a patient with successfully treated acute promyelocytic leukaemia / Leuk Lymphoma 44 : 895 ~ 896
Felice MS / 1999 / Acute trilineage leukemia with monosomy of chromosome 7 following an acute promyelocytic leukemia / Leuk Lymphoma 34 : 409 ~ 413
Garcia-Manero G / 2002 / Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL) / Leukemia 16 : 1888 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0