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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 113 - 116 (4page)
이용수
초록· 키워드
오류제보하기
Cementum is the mineralized tissue of the tooth. It is
similar to bone in several aspects but it differs from bone.
Human bone marrow stromal cells (BMSC) and human
cementum derived cells (HCDC) (10,000 cells/cm
2
) were
plated in 6 well plates as feeder cells. The next day, mouse
bone marrow cells (1.5 million cells/cm
2
) were added. One
group of these plates were incubated in serum-free conditioned
medium (SFCM) generated from BMSC or HCDC supplemented
with 2% FBS, parathyroid hormone (PTH), 1, 25
dihydroxyvitamin D3 (Vit. D3) and dexamethasone, or plain
medium with the same supplements. Another group of
plates were cocultured with BMSC or HCDC in plain
medium supplemented with 2% FBS, PTH, Vit. D3 and
dexamethasone. Plates grown without SFCM or coculture
were used as controls. After 10 days, the cells were stained
for tartrate-resistant acid phosphatase (TRAP). BMSC
were found to support osteoclast formation under normal
conditions. This was inhibited however by both SFCM
generated from HCDC and also by coculture with HCDC.
In addition, HCDC themselves did not support osteoclast
formation under any conditions. Our results thus indicate
that HCDC do not support osteoclast formation in vitro and
that soluble factor (s) from HCDC may inhibit this process.
In addition, we show that this inhibition also involves an
active mechanism that is independent of osteoprotegerin, a
feature that may distinguish cementoblasts from other cells
present in periodontium.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bell N / 2003 / RANK ligand and modulation of skeletal remodeling / Journal of Clinical Investigation 111 : 1120 ~ 1122
Bianco P / 1998 / A miniature of human fibrous dysplasia of bone reproduced in immunodeficient mice by transplantation of mosaics of normal and Gs alpha-mutated marrow stroma
Bosshardt DD / 1996 / Cementogenesis reviewed : A comparison between human premolars and rodent molars / Anatomical Record? 245 : 267 ~ 292
Freeman E. Periodontium / 1994 / Oral Histology / Mosby-Year Book, Inc., St. Louis, MO, U.S.A : 276 ~ 312
Grzesik WJ / 1998 / Normal human cementum-derived cells: isolation, clonal expansion and in vitro and in vivo characterization / Journal of Bone and Mineral Research 13 : 154
Bianco P / 1998 / A miniature of human fibrous dysplasia of bone reproduced in immunodeficient mice by transplantation of mosaics of normal and Gs alpha-mutated marrow stroma
Bosshardt DD / 1996 / Cementogenesis reviewed : A comparison between human premolars and rodent molars / Anatomical Record? 245 : 267 ~ 292
Freeman E. Periodontium / 1994 / Oral Histology / Mosby-Year Book, Inc., St. Louis, MO, U.S.A : 276 ~ 312
Grzesik WJ / 1998 / Normal human cementum-derived cells: isolation, clonal expansion and in vitro and in vivo characterization / Journal of Bone and Mineral Research 13 : 154
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