지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 51 - 57 (7page)
- DOI
- 10.15188/kjopp.2015.02.29.1.51
이용수
초록· 키워드
오류제보하기
Bone destruction is a pathological symptom of some chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of these diseases results from increased number and activity of osteoclasts. Paeoniae Radix Alba has been used in korean traditional medicine to treat disease including inflammation, gynecopathy and various pain. However, these effects have not been tested on osteoclasts, the bone resorbing cells that regulate bone metabolism. Here, we investigated the effects of Paeoniae Radix Alba ethanol extract (PRAE) on receptor activator of nuclear factor-kappa B ligand (RANKL)-mediated osteoclast differentiation and formation. Osteoclast differentiation and formation were measured by tartrate resistant acidic phosphatase (TRAP) staining and TRAP solution assay. The treatment of PRAE on bone marrow derived macrophages (BMMs), which is known as osteoclast precursor cells, inhibited osteoclast differentiation and formation in a dose-dependent manner. In addition, the expression of osteoclast differentiation marker genes was suppressed by PRAE treatment. This inhibitory effect of PRAE resulted from significant repression of c-Fos expression, and subsequent reduction of NFATc1 expression which was previously reported as a master transcription factor for osteoclastogenesis in vitro and in vivo . These results demonstrate that PRAE negatively regulates osteoclast differentiation and formation and suggest that PRAE can be used as a potent preventive or therapeutic candidate for various bone diseases, such as postmenopausal osteoporosis, periodontitis and rheumatoid arthritis.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Walsh, M. C. / 2006 / Osteoimmunology: interplay between the immune system and bone metabolism / Annu Rev Immuno.l 24 : 33 ~ 63
2. [학술지(정기간행물)] - Suda, T. / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr Rev 20 (3) : 345 ~ 357
3. [학술지(정기간행물)] - Lee, Z. H. / 2003 / Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts / Biochem Biophys Res Commun 305 (2) : 211 ~ 214
4. [학술지(정기간행물)] - Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
5. [학술지(정기간행물)] - Teitelbaum, S. L. / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4 (8) : 638 ~ 649
2. [학술지(정기간행물)] - Suda, T. / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr Rev 20 (3) : 345 ~ 357
3. [학술지(정기간행물)] - Lee, Z. H. / 2003 / Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts / Biochem Biophys Res Commun 305 (2) : 211 ~ 214
4. [학술지(정기간행물)] - Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
5. [학술지(정기간행물)] - Teitelbaum, S. L. / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4 (8) : 638 ~ 649
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
동의생리병리학회지
2015 .01
-
Origin of Osteoclasts: Osteoclast Precursor Cells
대한골대사학회지
2023 .05
-
Osteoclasts: Crucial in Rheumatoid Arthritis
대한류마티스학회지
2016 .01
-
소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향
대한한의학회지
2017 .09
-
Inhibitory effect of Chaenomelis Fructus ethanol extract on receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis
International Journal of Oral Biology
2020 .01
-
Extracts of Flavoparmelia sp. Inhibit Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation
대한골대사학회지
2019 .01
-
RANKL에 의한 파골세포의 분화 억제에 대한 isorhamnetin의 효과
생약학회지(Korean Journal of Pharmacognosy)
2023 .12
-
극지해면동물 Sphaerotylus antarcticus 추출물의 RANKL 유도 파골세포 분화 및 ROS 생성 억제 효과
생약학회지(Korean Journal of Pharmacognosy)
2022 .03
-
RANK Signaling Pathways and Key Molecules Inducing Osteoclast Differentiation
대한의생명과학회지
2017 .12
-
녹제초 추출물이 파골세포 분화 및 골 흡수에 미치는 영향
한방재활의학과학회지
2019 .01
-
계혈등 에탄올 추출물의 RANKL 처리 RAW264.7 세포의 분화와 염증성 골 손실에 미치는 영향
대한한방내과학회지
2022 .12
-
Piperlongumine suppressed osteoclastogenesis in RAW264.7 macrophages
International Journal of Oral Biology
2019 .01
-
Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts
Journal of Korean Medical Science
2021 .09
-
Effect of remifentanil on pre-osteoclast cell differentiation in vitro
Journal of dental anesthesia and pain medicine
2018 .01
-
The Role of Toll-Like Receptors in Osteoclastogenesis
대한골대사학회지
2020 .01
-
치자 추출물이 RANKL 유도 파골세포 형성 및 골 흡수에 미치는 영향
대한한방내과학회지
2017 .01
-
Attenuation of RANKL-induced Osteoclast Formation via p38-mediated NFATc1 Signaling Pathways by Extract of Euphorbia Lathyris L
대한골대사학회지
2016 .01
-
Fexaramine Inhibits Receptor Activator of Nuclear Factor-κB Ligand-induced Osteoclast Formation via Nuclear Factor of Activated T Cells Signaling Pathways
대한골대사학회지
2017 .01
-
A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation
대한의생명과학회지
2017 .09
-
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
대한류마티스학회지
2016 .01
이 논문과 함께 이용한 논문
작약의 혈소판 응집억제작용에 관한 연구
서범석
,
박관혁
,
손동주
외 2명
한국산학기술학회 학술대회논문집
2003
.06
RANKL 유도된 파골세포 분화에 대한 풀무치 에탄올 추출물의 분화 억제 효과
백민희
,
서민철
,
이준하
외 6명
생명과학회지
2019
.10
호두복합추출물이 골수유래대식세포의 파골세포 분화에 미치는 효과
공해진
,
강재희
,
유화연
외 1명
동의생리병리학회지
2019
.06
Ellagic Acid가 조골세포 분화에 미치는 영향
손효은
,
김은아
,
변미순
외 1명
한국식품영양과학회지
2019
.03
모싯잎의 난소절제 생쥐에 대한 골다공증 조절 효과
김남석
,
김하림
,
이득주
외 7명
한국식품영양과학회지
2018
.02
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-519-001127101