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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 143 - 148 (6page)
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초록· 키워드
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Osteoclasts are multinucleated cells with bone resorbing activity and differentiated from hematopoietic cell lineages of monocyte/macrophages in the presence of receptor activator of NF-κB ligand (RANKL) and M-CSF. However, the exact molecular mechanisms through which RANKLstimulates osteoclastogenesis remain to be elucidated. Herewe report that activation of cAMP-response elementbinding protein (CREB) is not involved in osteoclastogenesis from osteoclast precursors in response to RANKL.RANKL induced CREB activation in osteoclast precursors. Using pharmacological inhibitors, we found that RANKLinduced CREB activation is dependent on p38 MAPK pathways. We also found that ectopic expressions of wild type and dominant negative forms of CREB in osteoclast precursors did not affect RANKL-induced osteoclast formation and bone resorbing activity. Furthermore, dominant negative forms of CREB did not alter the expression levels of osteoclast-specific marker genes. Taken together, these data suggest that CREB is dispensable for differentiation and resorbing activity of osteoclasts.
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참고문헌 (29)
참고문헌 신청
/ 1988 / structure based on a cloned placental cDNA : 1430 ~ 242 1433
/ 1989 / A cluster of phosphorylation sites on the cyclic AMP- regulated nuclear factor CREB predicted by its sequence : 749 ~ 337 752
/ 1989 / Cyclic AMP stimulates somatostatin genetranscription by phosphorylation of CREB at serine 133 : 675 ~ 59 680
/ 1990 / a cornucopia of transcription factors endocri (l) : 1087 ~ 1094
/ 1992 / Modulation of osteoclast diferentiation : 66 ~ 80
/ 1989 / A cluster of phosphorylation sites on the cyclic AMP- regulated nuclear factor CREB predicted by its sequence : 749 ~ 337 752
/ 1989 / Cyclic AMP stimulates somatostatin genetranscription by phosphorylation of CREB at serine 133 : 675 ~ 59 680
/ 1990 / a cornucopia of transcription factors endocri (l) : 1087 ~ 1094
/ 1992 / Modulation of osteoclast diferentiation : 66 ~ 80
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