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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Osteoporosis is a geriatric disease with diminished bone density. The increase in the number of patients and medical expenses due to a global aging society are recognized as problems. Bone loss is the most common symptom of bone disease, not only osteoporosis but Paget's disease, rheumatoid arthritis, multiple myeloma, and other diseases. The main cause of this symptoms is excessive increase in the number and activity of osteoclasts. Osteoclasts are multinucleated giant cells that can resorb bone. They are differentiated and activation from monocytes/macrophages in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL). Methods: The effect of extract of Flavoparmelia sp. (EFV), a genus of lichenized fungi within the Parmeliaceae, on the differentiation of bone marrow-derived macrophages (BMMs) into osteoclasts was examined by phenotype assay and the cell cytotoxicity was evaluated by cell counting kit-8. The osteoclast differentiation-related genes and proteins were investigated by real-time polymerase chain reaction and immunoblotting. The functional activity of osteoclast in response to EFV treatment was evaluated by an Osteo Assay plate. Results: In this study, we found that EFV, a genus of lichenized fungi within the Parmeliaceae, inhibited osteoclast formation. And we investigated its inhibitory mechanism. EFV reduced RANKL-mediated osteoclast formation and activation by inhibiting expression of nuclear factor of activated T cells 1, a key factor of osteoclastogenesis. Conclusions: Taken together, our results show that EFV is a promising candidate for health functional foods or therapeutic agents that can help treat bone diseases such as osteoporosis.
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참고문헌 (41)
참고문헌 신청
Manolagas SC / 2000 / Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis / Endocr Rev 21:115~137
Finkelstein JS / 2008 / Bone mineral density changes during the menopause transition in a multiethnic cohort of women / J Clin Endocrinol Metab 93:861~868
Kanis JA / 2001 / Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds / Osteoporos Int 12:989~995
Tella SH / 2014 / Prevention and treatment of postmenopausal osteoporosis / J Steroid Biochem Mol Biol 142:155~170
Riggs BL / 2005 / Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling / J Bone Miner Res 20:177~184
Finkelstein JS / 2008 / Bone mineral density changes during the menopause transition in a multiethnic cohort of women / J Clin Endocrinol Metab 93:861~868
Kanis JA / 2001 / Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds / Osteoporos Int 12:989~995
Tella SH / 2014 / Prevention and treatment of postmenopausal osteoporosis / J Steroid Biochem Mol Biol 142:155~170
Riggs BL / 2005 / Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling / J Bone Miner Res 20:177~184
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