지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 35 - 42 (8page)
이용수
초록· 키워드
오류제보하기
The use of bacteria in the treatment of cancer has a long and interesting history. The use of live bacteria in this way however has a number of potential problems including toxicity. Purified low molecular weight bacterial proteins have therefore been tested as anticancer agents to avoid such complications. Oral cancer is a widely occurring disease around the world and these lesions are typically very resistant to anticancer agents. In our present study we investigated the effects of purified recombinant azurin from Pseudomonas (P.) aeruginosa against YD-9 (p53-positive)human oral squamous carcinoma cells. Azurin showed cytotoxic effects against these cells in a dose dependent manner. The cell death accompanied by this treatment was found to be characterized by chromatin condensation and apoptotic bodies. Azurin treatment was further found to increase the expression of p53 The stabilization of p53 and induction of apoptosis in YD-9 cells by azurin suggests that it has potentially very strong anticancer properties in oral squamous carcinoma.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Agrawal N / 2004 / Bacteriolytic therapy can generate a potent immune response against experimental tumors / Proc Natl Acad Sci U S A 101 : 15172 ~ 15177
Apiyo D / 2005 / Unique complex between bacterial azurin and tumor-suppressor protein p53 / Biochem. Biophys. Res Commun 332 : 965 ~ 968
Bickels J / 2002 / Coley's toxin: Historical perspective / Isr Med Assoc J 4 : 471 ~ 472
Chaudhari A / 2007 / Cupredoxin-cancer interrelationship:azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth / Biochemi
Coley WB / 1893 / The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases / Am J Med Sci 105 : 487 ~ 411
Apiyo D / 2005 / Unique complex between bacterial azurin and tumor-suppressor protein p53 / Biochem. Biophys. Res Commun 332 : 965 ~ 968
Bickels J / 2002 / Coley's toxin: Historical perspective / Isr Med Assoc J 4 : 471 ~ 472
Chaudhari A / 2007 / Cupredoxin-cancer interrelationship:azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth / Biochemi
Coley WB / 1893 / The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases / Am J Med Sci 105 : 487 ~ 411
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Bacterial Protein Azurin Enhances Sensitivity of Oral Squamous Carcinoma Cells to Anticancer Drugs
Yonsei Medical Journal
2011 .01
-
한국인에서 구강 편평세포암종의 5년 생존율
대한구강악안면외과학회지
2009 .01
-
Dual effects of honokiol as an anti-inflammatory and anticancer drug in human oral squamous cancer cells and xenograft
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70)
Yonsei Medical Journal
2010 .01
-
黃連이 구강암 세포에서의 세포자멸사에 미치는 영향
한방안이비인후피부과학회지
2009 .01
-
Norcantharidin induces apoptotic cell death of human oral squamous cell carcinoma cells via activation of p38 MAPK
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Mechanism Underlying NaF-Induced Apoptosis in Human Oral Squamous Cell Carcinoma
International Journal of Oral Biology
2010 .01
-
Recurrence and Salvage Treatment of Squamous Cell Carcinoma of the Oral Cavity
대한두경부종양학회 학술대회
2006 .01
-
Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review
Imaging science in dentistry
2018 .01
-
유방의 원발성 편평상피암종의 세침흡인 세포학적 소견 - 1예 보고 -
대한세포병리학회지
1996 .01
-
Primary Squamous Cell Carcinoma of the Liver
한국간담췌외과학회 학술대회지
2012 .04
-
선택적 COX-2 저해를 통한 구강암세포주KB의 침습성 변화에 관한 예비연구
대한구강악안면외과학회지
2007 .01
-
Recombinant Human Bone Morphogenetic Protein-2 in Development and Progression of Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Pseudomonas aeruginosa exotoxin A (PEA)가 사람혀편평암종세포에서 나타나는 세포자멸사 작용
한국치위생학회지
2014 .01
-
전이성 편평 세포암종의 체액 세포학적 소견
대한세포병리학회지
1992 .01
-
Cyclosporin A가 구강편평상피세포암 세포주에 미치는 항암효과
대한구강악안면외과학회지
2004 .01
-
Growth inhibition by metformin in YD-38 oral cancer cells derived from Korean
Oral Biology Research
2017 .01
-
Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Oral Cavity
대한두경부종양학회 학술대회
2009 .01
-
식도암과 동반된 갑상선의 편평세포암종
대한기관식도과학회지
1997 .01
-
Effect of Resveratrol on Oral Cancer Cell Invasion Induced by Lysophosphatidic Acid
치위생과학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0