지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 773 - 778 (6page)
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Purpose: Surgical therapy is the primary treatment for oral cancer, but it can cause facial distortion. Therefore, if anticancer drugs are effective against oral cancer, they may be used preferentially. However, oral squamous carcinoma cells (OSCCs)are resistant to these drugs, so finding a way to enhance the sensitivity of these cells to anticancer drugs is important. The bacterial protein azurin is known to selectively enter cancer cells and induce apoptosis. In this study, we show the anticancer effect of azurin in OSCC. Materials and Methods: OSCC cell line (YD-9) was subjected to azurin treatment. Cell viability, morphology and protein expression levels were monitored after treatment of azurin. Cells were also subjected to combination treatment of azurin with either 5-fluorouracil or etopside. Results: Azurin-treated cells showed decreased cell viability accompanied by apoptotic phenotypes including morphological change, DNA breakage, and increases in p53 and cyclin B1 protein levels. Combination treatment of azurin with other anti-tumor agents caused an increase in sensitivity to anticancer drugs in azurin-treated YD-9 cells. Conclusion: Azurin has a strong synergistic anticancer effect on oral cancer cells when it is used along with anticancer drugs.
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참고문헌 (12)
참고문헌 신청
Borgne A / 2006 / Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment / Oncogene 25 : 7361 ~ 7372
Chen XX / 2002 / Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines / World J Gastroenterol 8
Gomez LA / 2007 / Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy / Mol Cancer Ther 6 : 1534 ~ 1543
Hooper SJ / 2009 / Exploring the link between microorganisms and oral cancer: a systematic review of the literature / Head Neck 31 : 1228 ~ 1239
Porter LA / 2000 / Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis / Blood 95 : 2645 ~ 2650
Chen XX / 2002 / Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines / World J Gastroenterol 8
Gomez LA / 2007 / Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy / Mol Cancer Ther 6 : 1534 ~ 1543
Hooper SJ / 2009 / Exploring the link between microorganisms and oral cancer: a systematic review of the literature / Head Neck 31 : 1228 ~ 1239
Porter LA / 2000 / Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis / Blood 95 : 2645 ~ 2650
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