지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 334 - 339 (6page)
이용수
초록· 키워드
오류제보하기
Background: Previous studies suggest that habitual exercise can improve skeletal mitochondrial function; however, to date, the association between exercise and mitochondrial function in peripheral leukocytes has not been report-ed. The aim of this study was to evaluate the relationship between regular exercise and mitochondrial function by measuring leukocyte mitochondrial DNA (mtDNA) copy number in postmenopausal women.Methods: This cross-sectional study included 144 relatively healthy, non-diabetic, non-smoking, postmenopausal women. Clinical parameters, including anthropometric measurements and cardio-metabolic parameters, were as-sessed. Regular exercise was defined as at least 150 minutes per week of moderate-intensity activity, or an equiva-lent combination of moderate and vigorous-intensity activity, over a duration of at least 6 months. Leukocyte mtD-NA copy numbers were measured using real-time polymerase chain reaction assays, and these were normalized to the -globin copy number to give the relative mtDNA copy number.Results: The mtDNA copy number of peripheral leukocytes was significantly greater in the exercise group (1.33±0.02) than in the no exercise group (1.05±0.02, P<0.01). Stepwise multiple regression analysis showed that regular exercise was independently associated with mtDNA copy number ( =0.25, P<0.01) after adjusting for the variables age, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, homeostasis model assess-ment of insulin resistance value, and levels of high-density lipoprotein cholesterol, triglycerides, and homocysteine.Conclusion: Regular exercise is associated with greater leukocyte mtDNA copy number in postmenopausal wom-en.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
McBride HM / 2006 / Mitochondria: more than just a powerhouse / Curr Biol 16:R551~R560
Weinberg SE / 2015 / Mitochondria in the regulation of innate and adaptive immunity / Immunity 42:406~417
Carter HN / 2015 / Mitochondria, muscle health, and exercise with advancing age / Physiology (Bethesda) 30:208~223
Short KR / 2005 / Decline in skeletal muscle mitochondrial function with aging in humans / Proc Natl Acad Sci U S A 102:5618~5623
Clay Montier LL / 2009 / Number matters: control of mammalian mitochondrial DNA copy number / J Genet Genomics 36:125~131
Weinberg SE / 2015 / Mitochondria in the regulation of innate and adaptive immunity / Immunity 42:406~417
Carter HN / 2015 / Mitochondria, muscle health, and exercise with advancing age / Physiology (Bethesda) 30:208~223
Short KR / 2005 / Decline in skeletal muscle mitochondrial function with aging in humans / Proc Natl Acad Sci U S A 102:5618~5623
Clay Montier LL / 2009 / Number matters: control of mammalian mitochondrial DNA copy number / J Genet Genomics 36:125~131
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Association between Salivary Mitochondrial DNA Copy Number and Chronic Fatigue according to Combined Symptoms in Korean Adults
Korean Journal of Family Medicine
2017 .07
-
Clinicopathological Implications of Mitochondrial Genome Alterations in Pediatric Acute Myeloid Leukemia
Annals of Laboratory Medicine
2016 .01
-
Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia
Blood Research
2018 .01
-
Mitochondrial DNA Aberrations and Pathophysiological Implications in Hematopoietic Diseases, Chronic Inflammatory Diseases, and Cancers
Annals of Laboratory Medicine
2015 .01
-
노인의 운동의도, 운동습관, 운동자기효능감이 규칙적 운동행위에 미치는 영향
근관절건강학회지
2019 .12
-
Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
Yonsei Medical Journal
2019 .01
-
The Stability of Blood Gas Parameters Depends on Leukocyte Counts
Annals of Laboratory Medicine
2021 .09
-
Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head
대한체질인류학회 학술대회 연제 초록
2020 .08
-
Alteration of mitochondrial DNA content modulates antioxidant enzyme expressions and oxidative stress in myoblasts
The Korean Journal of Physiology & Pharmacology
2019 .01
-
운동이 약이다: 의학은 핵심적 치료 도구인 운동을 어떻게 끌어안아야 하는가?
대한의사협회지
2024 .09
-
Letter to the Editor: Depending on the Disease Stage and Modifying Factors, mtDNA-Associated Hearing Loss Can Occur With Many mtDNA Mutations
Journal of Korean Medical Science
2024 .01
-
골관절염 노인의 운동지속 경험 : 포커스 집단면접
근관절건강학회지
2018 .04
-
The Author Reply: Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
Yonsei Medical Journal
2019 .01
-
Integrated analysis of microRNA and mRNA expressions in peripheral blood leukocytes of Warmblood horses before and after exercise
Journal of Veterinary Science
2018 .01
-
당뇨 환자의 운동실천에 따른 건강행태, 의료이용 및 의료비용 비교
지역사회간호학회지
2015 .03
-
남성 생산직과 사무직 근로자의 운동행위에 영향을 미치는 요인: Pender의 건강증진 모형을 활용
한국직업건강간호학회지
2015 .01
-
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
Diabetes and Metabolism Journal
2022 .05
-
Mitochondrial DNA 4977bp Deletion Mutation in Peripheral Blood Reflects Atrial Remodeling in Patients with Non-Valvular Atrial Fibrillation
Yonsei Medical Journal
2015 .01
-
간호대학생을 위한 복합운동과 운동습관형성 프로그램 개발 및 효과검증
기본간호학회지
2020 .11
-
근감소증 예방을 위한 저항성 운동의 실제적 적용
Annals of geriatric medicine and research
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0