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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 206 - 212 (7page)
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초록· 키워드
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Background: We examined the association between salivary mitochondrial DNA (mtDNA) copy number and chronic fatigue combined with depression and insomnia.Methods: This cross-sectional study included 58 healthy adults with moderate to severe fatigue (Brief Fatigue In-ventory [BFI] ≥4) for longer than 6 months. Subjects were classified as those without combined symptoms, with ei-ther depression (Beck Depression Inventory [BDI] ≥13) or insomnia (Pittsburgh Sleep Quality Index [PSQI] ≥5), or with both depression and insomnia. Salivary mtDNA copy number was measured by real-time quantitative poly-merase chain reaction. The association was evaluated using a general linear model.Results: About 76% of participants had either depression or insomnia as additional symptoms. These subjects were predominately female, drank more alcohol, and exercised less than those without combined symptoms (P<0.05). The group with both depression and insomnia exhibited significantly higher BFI and lower mtDNA copy number than those without combined symptoms (P<0.05). After adjusting for confounding factors, significant negative as-sociations between mtDNA copy number and usual fatigue were found in the group without combined symptoms, whereas the negative associations in the group with combined symptoms were attenuated. BDI and PSQI were not associated with mtDNA copy number.Conclusion: Chronic fatigue is negatively associated with salivary mtDNA copy number. Salivary mtDNA copy number may be a biological marker of fatigue with or without combined symptoms, indicating that a separate ap-proach is necessary.
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참고문헌 (31)
참고문헌 신청
Yun YH / 2008 / Fatigue in the general Korean population : application and normative data of the Brief Fatigue Inventory / J Pain Symptom Manage 36:259~267
Robinson RL / 2015 / The importance of unresolved fatigue in depression : costs and comorbidities / Psychosomatics 56:274~285
Wong WS / 2012 / The co-morbidity of chronic pain, insomnia, and fatigue in the general adult population of Hong Kong: prevalence and associated factors / J Psychosom Res 73:28~34
Kallestad H / 2015 / The role of insomnia in the treatment of chronic fatigue / J Psychosom Res 78:427~432
Schwarz R / 2003 / Fatigue in the general population / Onkologie 26:140~144
Robinson RL / 2015 / The importance of unresolved fatigue in depression : costs and comorbidities / Psychosomatics 56:274~285
Wong WS / 2012 / The co-morbidity of chronic pain, insomnia, and fatigue in the general adult population of Hong Kong: prevalence and associated factors / J Psychosom Res 73:28~34
Kallestad H / 2015 / The role of insomnia in the treatment of chronic fatigue / J Psychosom Res 78:427~432
Schwarz R / 2003 / Fatigue in the general population / Onkologie 26:140~144
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