지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 53 - 61 (9page)
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초록· 키워드
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Purpose: Recently, mitochondrial DNA 4977bp deletion (mtDNA4977-mut), a somaticmutation related to oxidative stress, has been shown to be associated with atrial fibrillation (AF). We hypothesized that patient age, as well as electroanatomicalcharacteristics of fibrillating left atrial (LA), vary depending on the presence of mtDNA4977-mut in peripheral blood among patients with non-valvular AF. Materials and Methods: Analyzing clinical and electroanatomical characteristics, we investigated the presence of the mtDNA4977-mut in peripheral blood of 212 patients (51.1±13.2 years old, 83.5% male) undergoing catheter ablation for non-valvular AF, as well as 212 age-matched control subjects. Results: The overall frequencyof peripheral blood mtDNA4977-mut in patients with AF and controls was not significantly different (24.5% vs. 19.3%, p=0.197). When the AF patient group was stratified according to age, mtDNA4977-mut was more common (47.4% vs. 20.0%, p=0.019) in AF patients older than 65 years than their age-matched controls.
Among AF patients, those with mtDNA4977-mut were older (58.1±11.9 years old vs. 48.8±11.9 years old, p<0.001). AF patients positive for the mtDNA mutation had greater LA dimension (p=0.014), higher mitral inflow peak velocity (E)/diastolic mitral annular velocity (Em) ratio (p<0.001), as well as lower endocardialvoltage (p=0.035), and slower conduction velocity (p=0.048) in the posteriorLA than those without the mutation. In multivariate analysis, E/Em ratio was found to be significantly associated with the presence of mtDNA4977-mut in peripheralblood. Conclusion: mtDNA4977-mut, an age-related somatic mutation detected in the peripheral blood, is associated with advanced age and electro-anatomicalremodeling of the atrium in non-valvular AF.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Rudolph V / 2010 / Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation / Nat Med 16:470~474
Richter B / 2012 / Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation / Clin Res Cardiol 101:217~225
Bonilla IM / 2012 / Nitric oxide synthases and atrial fibrillation / Front Physiol 3:105
Yoshida H / 2012 / AMP-activated protein kinase connects cellular energy metabolism to KATP channel function / J Mol Cell Cardiol 52:410~418
Sasaki N / 2001 / ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes / Am J Physiol Heart Circ Physiol 280:H1882~H1888
Richter B / 2012 / Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation / Clin Res Cardiol 101:217~225
Bonilla IM / 2012 / Nitric oxide synthases and atrial fibrillation / Front Physiol 3:105
Yoshida H / 2012 / AMP-activated protein kinase connects cellular energy metabolism to KATP channel function / J Mol Cell Cardiol 52:410~418
Sasaki N / 2001 / ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes / Am J Physiol Heart Circ Physiol 280:H1882~H1888
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