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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 135 - 153 (19page)
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The aromatic amino acids, which are composed of ʟ-phenylalanine, ʟ-tyrosine and ʟ-tryptophan, are general components of protein synthesis as well as precursors for a wide range of secondary metabolites. These aromatic amino acids-derived compounds play important roles as ingredients of diverse phenolics including pigments and cell walls, and hormones like auxin and salicylic acid in plants. Moreover, they also serve as the natural products of alkaloids and glucosinolates, which have a high potential to promote human health and nutrition. The biosynthetic pathways of aromatic amino acids share a chorismate, the common intermediate, which is originated from shikimate pathway.
Then, tryptophan is synthesized via anthranilate and the other phenylalanine and tyrosine are synthesized via prephenate, as intermediates. This review reports recent studies about all the enzymatic steps involved in aromatic amino acid biosynthetic pathways and their gene regulation on transcriptional/posttranscriptional levels. Furthermore, results of metabolic engineering are introduced as efforts to improve the production of the aromatic amino acids-derived secondary metabolites in plants.
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참고문헌 (23)
참고문헌 신청
Anton IA / 1988 / Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase / Biochem J 249 : 319 ~ 326
Arabidopsis Genome Initiat / 2000 / Analysis of the genome sequence of the flowering plant Arabidopsis thaliana / Nature 408 : 796 ~ 815
Barends TRM / 2008 / Tryptophan synthase, an allosteric molecular factory / Curr Opin Chem Biol 12 : 593 ~ 600
Bartee L / 2001 / Two Arabidopsis methylation-deficiency mutations confer only partial effects on a methylated endogenous gene family / Nucleic Acids Res 29 : 2127 ~ 2134
Basset G / 2004 / Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids / Proc Natl Acad Sci US
Arabidopsis Genome Initiat / 2000 / Analysis of the genome sequence of the flowering plant Arabidopsis thaliana / Nature 408 : 796 ~ 815
Barends TRM / 2008 / Tryptophan synthase, an allosteric molecular factory / Curr Opin Chem Biol 12 : 593 ~ 600
Bartee L / 2001 / Two Arabidopsis methylation-deficiency mutations confer only partial effects on a methylated endogenous gene family / Nucleic Acids Res 29 : 2127 ~ 2134
Basset G / 2004 / Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids / Proc Natl Acad Sci US
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