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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 292 - 304 (13page)
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High value-added therapeutic proteins have been leading the biologics industry and occupied major portion of the market. More than 60% of the currently available protein therapeutics are glycoproteins attached with glycans which play crucial roles for the protein folding, therapeutic efficacy,in vivo half-life and immunogenecity. This review introduces the process of glycosylation and the impacts of glycans in the aspects of therapeutics. The important glycan structures in therapeutic performances were also summarized focusing on three representative categories of glycoproteins,cytokines, therapeutic antibody and enzyme. Currently, mammalian expression systems such as Chinese hamster ovary cells are preferred for the production of therapeutic glycoproteins due to their ability to synthesize glycans having similar structures with human type glycans. However, recent advances of plant glycoengineering to overcome the limitation originating from different glycan structures will soon allow to develop more efficient and economic plant-based production systems for therapeutic glycoproteins.
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참고문헌 (25)
참고문헌 신청
/ / FDA (US Food and Drug Administration) website
Aebi M / 2010 / N-glycan structures: recognition and processing in the ER / Trends Biochem Sci 35 : 74 ~ 82
Anthony RM / 2008 / Recapitulation of IVIG antiinflammatory activity with a recombinant IgG Fc / Science 320 : 373 ~ 376
Ashwell G / 1978 / A protein from mammalian liver that specifically binds galactose-terminated glycoproteins / Methods Enzymol 50 : 287 ~ 288
Boyd PN / 1995 / The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of Campath-1H / Mol Immunol 32 : 1311 ~ 1318
Aebi M / 2010 / N-glycan structures: recognition and processing in the ER / Trends Biochem Sci 35 : 74 ~ 82
Anthony RM / 2008 / Recapitulation of IVIG antiinflammatory activity with a recombinant IgG Fc / Science 320 : 373 ~ 376
Ashwell G / 1978 / A protein from mammalian liver that specifically binds galactose-terminated glycoproteins / Methods Enzymol 50 : 287 ~ 288
Boyd PN / 1995 / The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of Campath-1H / Mol Immunol 32 : 1311 ~ 1318
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