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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.4 No.2
- 발행연도
- 1999.6
- 수록면
- 117 - 121 (5page)
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초록· 키워드
오류제보하기
The antitumor and immunologic activities of the glycoproteins extracted from sea cucumber (Stichopus japonicus) on mice bearing sarcoma 180 cells were investigated. Maximum tumor suppression (64%) occurred at the dose of 100 ㎎ glycoprotein/㎏. The highest prolongation ratio was achieved at the level of 100 ㎎/㎏ and increased by 39% more than that of control. Glycoproteins from sea cucumber exhibited direct cytotoxic effect on the tumor cells. Dose-dependent increase of leucocyte, peritoneal exudate cell and weights of immunoorgans revealed the improvement of immunity. When the glycoprotein-administered group was compared with the control, a significant difference was not noted in the clinico-chemical values such as S-GOT, S-GPT, alkaline phosphatase activity, total protein, cholesterol, triglyceride, urea nitrogen and glucose levels in blood. These results suggest that the antitumor activity of sea cucumber glycoprotein is associated with activation of cells in the immune system.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018075088