지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.4
- 발행연도
- 2014.12
- 수록면
- 307 - 313 (7page)
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The effect of various levels of proteins, sulfates, and molecular weight (Mw) of a sulfated-glycoprotein (NF₃) from a sea cucumber, Stichopus japonicus, on nitric oxide (NO) releasing capacity from RAW 264.7 cells was investigated. The NF₃ derivatives had various amounts of proteins (4.8∼11.2%) and sulfates (6.8∼25.2%) as well as different Mw (640.3×10³∼109.2×10³ g/㏖). NF3 was able to stimulate RAW 264.7 cells to release NO with lower protein contents, indicating that the protein moiety was not an important factor to stimulate macrophages. On the other hand, the NO inducing capacity was significantly reduced with decreased levels of sulfates and Mw, implying that sulfates and Mw played a pivotal role in activating RAW 264.7 cells. It was not clear why sulfates and a certain range of Mw were essential for stimulating macrophages. It appeared that certain levels of sulfates and Mw of sulfated-glycoproteins were required to bind to the surface receptors on RAW 264.7 cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Pomin VH / 2005 / Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity / Glycobiology 15 : 369 ~ 381
2. [학술지(정기간행물)] - Mao WJ / 2008 / Heparinoid-active two sulfated polysaccharides isolated from marine green algae Monostroma nitidum / Carbohydr Polym 74 : 834 ~ 839
3. [학술지(정기간행물)] - Riou D / 1996 / Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line / Anticancer Res 16 : 1213 ~ 1218
4. [학술지(정기간행물)] - 유영춘 / 2007 / Immunomodulating Activity of a Fucoidan Isolated from Korean Undaria pinnatifida Sporophyll / ALGAE 22 (4) : 333 ~ 338
5. [학술지(정기간행물)] - Soeda S / 2000 / Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells: its possible mechanism of action / Biochim Biophys Acta 1497 : 127 ~ 134
2. [학술지(정기간행물)] - Mao WJ / 2008 / Heparinoid-active two sulfated polysaccharides isolated from marine green algae Monostroma nitidum / Carbohydr Polym 74 : 834 ~ 839
3. [학술지(정기간행물)] - Riou D / 1996 / Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line / Anticancer Res 16 : 1213 ~ 1218
4. [학술지(정기간행물)] - 유영춘 / 2007 / Immunomodulating Activity of a Fucoidan Isolated from Korean Undaria pinnatifida Sporophyll / ALGAE 22 (4) : 333 ~ 338
5. [학술지(정기간행물)] - Soeda S / 2000 / Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells: its possible mechanism of action / Biochim Biophys Acta 1497 : 127 ~ 134
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UCI(KEPA) : I410-ECN-0101-2016-594-001045101