지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 470 - 484 (15page)
- DOI
- 10.1038/s12276-023-00939-9
이용수
초록· 키워드
오류제보하기
Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and tumor cells metastasize to distant organs via blood vessels. However, whether tumor invasion is associated with blood vessels remains unknown. As glioblastoma (GBM) is featured by aggressive invasion and vascular abnormalities, we characterized the onset of vascular remodeling in the diffuse tumor infiltrating zone by establishing new spontaneous GBM models with robust invasion capacity. Normal brain vessels underwent a gradual transition to severely impaired tumor vessels at the GBM periphery over several days. Increasing vasodilation from the tumor periphery to the tumor core was also found in human GBM. The levels of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) showed a spatial correlation with the extent of vascular abnormalities spanning the tumor-invading zone. Blockade of VEGFR2 suppressed vascular remodeling at the tumor periphery, confirming the role of VEGF-VEGFR2 signaling in the invasion-associated vascular transition. As angiopoietin-2 (ANGPT2) was expressed in only a portion of the central tumor vessels, we developed a ligand-independent tunica interna endothelial cell kinase 2 (Tie2)-activating antibody that can result in Tie2 phosphorylation in vivo. This agonistic anti-Tie2 antibody effectively normalized the vasculature in both the tumor periphery and tumor center, similar to the effects of VEGFR2 blockade. Mechanistically, this antibody-based Tie2 activation induced VE-PTP-mediated VEGFR2 dephosphorylation in vivo. Thus, our study reveals that the normal-to-tumor vascular transition is spatiotemporally associated with GBM invasion and may be controlled by Tie2 activation via a novel mechanism of action.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Structure and function of vascular endothelial growth factor and its receptor system
BMB Reports
2018 .01
-
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis
Experimental and Molecular Medicine
2017 .01
-
Normalization of Tumor Vessels through Activation of Tie2 Pathway and Conversion of Tumor Microenvironment by Oxygen Delivery
한국생물공학회 학술대회
2023 .10
-
Normalization of Tumor Vasculature through Activation of the Tie2 Pathway and Transformation of the Tumor Microenvironment by Oxygen Delivery
한국생물공학회 학술대회
2024 .09
-
Engineering of vascularized 3D cancer on a chip modeling for drug delivery
대한기계학회 춘추학술대회
2021 .04
-
형태학적 연산과 뇌종양 평균 크기를 이용한 감마나이프 치료 범위 자동 검출 알고리
멀티미디어학회논문지
2015 .10
-
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Experimental and Molecular Medicine
2020 .09
-
Rebuilding the microenvironment of primary tumors in humans: a focus on stroma
Experimental and Molecular Medicine
2024 .03
-
Interactions between tumor-derived proteins and Toll-like receptors
Experimental and Molecular Medicine
2020 .12
-
The origin-of-cell harboring cancer-driving mutations in human glioblastoma
BMB Reports
2018 .01
-
Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Experimental and Molecular Medicine
2023 .02
-
Tumor microenvironment and radioresistance
Experimental and Molecular Medicine
2021 .06
-
Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice
Experimental and Molecular Medicine
2019 .01
-
혈액-뇌종양 장벽 모사를 위한 3 차원 뇌종양 스페로이드 결합 미세유체 플랫폼
대한기계학회 춘추학술대회
2021 .04
-
Nanocomplex-Mediated in vivo CAR-M1 Macrophage Therapy for Solid Tumors
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Development of Tumor Microenvironment-Modulating Nanoparticles for Improved Anti-Tumor Efficacy of Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
In vitro Tumor Vasculature Model of the Colorectal Cancer Microenvrionment to Evaluate Natural Killer Cell Activity
대한기계학회 춘추학술대회
2021 .04
-
In Vitro Tumor Vasculature Model on an Injection-molded Microfluidic Platform
대한기계학회 춘추학술대회
2020 .08
-
miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling
BMB Reports
2017 .01
-
Brain Tumor Segmentation Study Through U-Net Architecture Modification
대한전자공학회 학술대회
2021 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0