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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 270 - 275 (6page)
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The Ubiquitin proteasome system (UPS) plays roles in protein degradation, cell cycle control, and growth and inflammatory cell signaling. Dysfunction of UPS in cardiac diseases has been seen in many studies. Cholesterol acts as an inducer of cardiac hypertrophy. In this study, the effect of proteasome inhibitors on the cholesterol-induced hypertrophic growth in H9c2 cells is examined in order to observe whether UPS is involved in cardiac hypertrophy. The treatment of proteasome inhibitors MG132 and Bortezomib markedly reduced cellular surface area and mRNA expression of -MHC in cholesterol-induced cardiac hypertrophy. In addition, activated AKT and ERK were significantly attenuated by MG132 and Bortezomib in cholesterol- induced cardiac hypertrophy. We demonstrated that cholesterol- induced cardiac hypertrophy was suppressed by proteasome inhibitors. Thus, regulatory mechanism of cholesterol- induced cardiac hypertrophy by proteasome inhibitors may provide a new therapeutic strategy to prevent the progression of heart failure.
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참고문헌 (36)
참고문헌 신청
Frey N / 2004 / Hypertrophy of the heart: a new therapeutic target? / Circulation 109:1580~1589
Glenn DJ / 2009 / Atrial natriuretic peptide suppresses endothelin gene expression, proliferation in cardiac fibroblasts through a GATA4-dependent mechanism / Cardiovasc Res 84:209~217
엄광현 / 2015 / Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy / BMB Reports 48(3):131~138
Glickman MH / 2002 / The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82:373~428
Hershko A / 1998 / The ubiquitin system / Annu Rev Biochem 67:425~479
Glenn DJ / 2009 / Atrial natriuretic peptide suppresses endothelin gene expression, proliferation in cardiac fibroblasts through a GATA4-dependent mechanism / Cardiovasc Res 84:209~217
엄광현 / 2015 / Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy / BMB Reports 48(3):131~138
Glickman MH / 2002 / The ubiquitinproteasome proteolytic pathway: destruction for the sake of construction / Physiol Rev 82:373~428
Hershko A / 1998 / The ubiquitin system / Annu Rev Biochem 67:425~479
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