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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 407 - 412 (6page)
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The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chondrocytes and in a mouse carrageenan-induced paw arthritis model. Western blotting and immunofluorescence analysis showed that PEP-1-FK506BP12 efficiently penetrated chondrocytes and cartilage explants. In interleukin-1 (IL-1)-treated chondrocytes, PEP-1-FK506BP12 significantly suppressed the expression of catabolic enzymes, including matrix metalloproteinases (MMPs)-1, -3, and -13 in addition to cyclooxygenase-2, at both the mRNA and protein levels, whereas FK506BP12 alone did not. In addition, PEP-1-FK506BP12 decreased IL-1-induced phosphorylation of the mitogen-activated protein kinase (MAPK) complex (p38, JNK, and ERK) and the inhibitor kappa B alpha.
In the mouse model of carrageenan-induced paw arthritis, PEP-1-FK506BP12 suppressed both carrageenan-induced MMP-13 production and paw inflammation. PEP-1-FK506BP12 may have therapeutic potential in the alleviation of OA progression.
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참고문헌 (24)
참고문헌 신청
[학술대회논문]
Cameron AM / 1995 / Calcineurin associated with the inositol 1, 4, 5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux / Cell 83 : 463 ~ 472
Fujii T / 2005 / Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts / J Biol Chem
Goldring MB / 2000 / The role of the chondrocyte in osteoarthritis / Arthritis Rheum 43 : 1916 ~ 1926
Goldring MB / 2004 / The regulation of chondrocyte function by proinflammatory mediators:prostaglandins and nitric oxide / Clin Orthop Relat Res 427 : 37 ~ 46
Cameron AM / 1995 / Calcineurin associated with the inositol 1, 4, 5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux / Cell 83 : 463 ~ 472
Fujii T / 2005 / Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts / J Biol Chem
Goldring MB / 2000 / The role of the chondrocyte in osteoarthritis / Arthritis Rheum 43 : 1916 ~ 1926
Goldring MB / 2004 / The regulation of chondrocyte function by proinflammatory mediators:prostaglandins and nitric oxide / Clin Orthop Relat Res 427 : 37 ~ 46
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