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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 112 - 117 (6page)
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Phospholipase D2 (PLD2) has been implicated in the tyrosine kinase-mediated signaling pathways, but the regulation events are yet to be identified. Herein, we demonstrate that pleckstrin homology (PH) domain of PLD2 (PLD2-PH) exerts an antitumorigenic effect via the suppression of PLD2 and focal adhesion kinase (FAK). The kinase domain of FAK interacts with PLD2-PH and induces tyrosine phosphorylation and activation of PLD2. Furthermore, PLD2 increased tyrosine phosphorylation of FAK. However, ectopic expression of the PLD2-PH competes for binding to FAK and reduces the interaction between PLD2 and FAK, thereby suppressing FAK-induced PLD activation and tyrosine phosphorylation of FAK. The PLD2-PH suppressed the migration and invasion of glioblastoma cells, as well as tumor formation in a xenograft mouse model. This study uncovers a novel role of PLD2-PH as a negative regulator of PLD2 and FAK.
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참고문헌 (26)
참고문헌 신청
Gomez-Cambronero J / 2014 / Phosphatidic acid, phospholipase D and tumorigenesis / Adv Biol Reg 54:197~206
Bruntz RC / 2014 / Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer / Pharmacol Rev 66:1033~1079
Nelson RK / 2015 / Physiological and pathophysiological roles for phospholipase D / J Lipid Res 56:2229~2237
Min DS / 2001 / Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431epidermoid carcinoma cells / Mol Cells 11:369~378
Kang DW / 2014 / Functional regulation of phospholipase D expression in cancer and inflammation / J Biol Chem 289:22575~22582
Bruntz RC / 2014 / Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer / Pharmacol Rev 66:1033~1079
Nelson RK / 2015 / Physiological and pathophysiological roles for phospholipase D / J Lipid Res 56:2229~2237
Min DS / 2001 / Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431epidermoid carcinoma cells / Mol Cells 11:369~378
Kang DW / 2014 / Functional regulation of phospholipase D expression in cancer and inflammation / J Biol Chem 289:22575~22582
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