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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 613 - 622 (10page)
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초록· 키워드
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RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chromatin modifiers and remodelers. However, to date, the variety of described mechanisms has made it difficult to understand precisely how these proteins work at the molecular level, and the contribution of their ATPase domain to these mechanisms remains unclear as well. In light of their association with long noncoding RNAs that are key epigenetic regulators, an emerging view is that DDX5 and DDX17 may act through modulating the activity of various ribonucleoprotein complexes that could ensure their targeting to specific chromatin loci. This review will comprehensively describe the current knowledge on these different mechanisms. We will also discuss the potential roles of DDX5 and DDX17 on the 3D chromatin organization and how these could impact gene expression at the transcriptional and post-transcriptional levels.
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참고문헌 (96)
참고문헌 신청
Bourgeois CF / 2016 / The multiple functions of RNA helicases as drivers and regulators of gene expression / Nat Rev Mol Cell Biol 17:426~438
Hirling H / 1989 / RNA helicase activity associated with the human p68 protein / Nature 339:562~564
Rossler OG / 2001 / Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72 / Nucleic Acids Res 29:2088~2096
Huang Y / 2002 / The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase / J Biol Chem 277:12810~12815
Fuller-Pace FV / 2013 / DEAD box proteins DDX5(p68) and DDX17 (p72): multi-tasking transcriptional regulators / Biochim Biophys Acta 1829:756~763
Hirling H / 1989 / RNA helicase activity associated with the human p68 protein / Nature 339:562~564
Rossler OG / 2001 / Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72 / Nucleic Acids Res 29:2088~2096
Huang Y / 2002 / The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase / J Biol Chem 277:12810~12815
Fuller-Pace FV / 2013 / DEAD box proteins DDX5(p68) and DDX17 (p72): multi-tasking transcriptional regulators / Biochim Biophys Acta 1829:756~763
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