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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 280 - 289 (10page)
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초록· 키워드
오류제보하기
Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases.
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등록된 정보가 없습니다.
참고문헌 (92)
참고문헌 신청
Ponting CP / 2010 / Transcribed dark matter: meaning or myth? / Hum Mol Genet 19:R162~R168
Lander ES / 2011 / Initial impact of the sequencing of the human genome / Nature 470:187~197
Fatica A / 2014 / Long non-coding RNAs: new players in cell differentiation and development / Nat Rev Genet 15:7~21
Quinn JJ / 2016 / Unique features of long non-coding RNA biogenesis and function / Nat Rev Genet 17:47~62
Wang Z / 2009 / RNA-Seq: a revolutionary tool for transcriptomics / Nat Rev Genet 10:57~63
Lander ES / 2011 / Initial impact of the sequencing of the human genome / Nature 470:187~197
Fatica A / 2014 / Long non-coding RNAs: new players in cell differentiation and development / Nat Rev Genet 15:7~21
Quinn JJ / 2016 / Unique features of long non-coding RNA biogenesis and function / Nat Rev Genet 17:47~62
Wang Z / 2009 / RNA-Seq: a revolutionary tool for transcriptomics / Nat Rev Genet 10:57~63
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