지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 535 - 540 (6page)
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초록· 키워드
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Reprogramming errors, which appear frequently in cloned animals,are reflected by aberrant gene expression. We previously reported the aberrant expression of TIMP-2 and PBEF in cloned placenta and differential expression of PBEF genes during pregnancy. To examine the epigenetic modifications that regulate dynamic gene expression in developing placentae, we herein analyzed the mRNA and protein expression levels of PBEF and TIMP-2 in the placentae of normal mice during pregnancy and then examined potential correlations with epigenetic modifications. DNA methylation pattern analysis revealed no difference, but ChIP assays using antibodies against H3-K9/K14 and H4-K5 histone acetylation revealed that the H3-K9/K14 acetylation levels, but not the H4-K5 acetylation levels, of the TIMP-2 and PBEF loci were significantly correlated with their gene expression levels during placentation in normal mice. These results suggest that epigenetic changes may regulate gene expression level in the developing placentae of normal mice and that inappropriate epigenetic reprogramming might be one cause of the abnormal placentae seen in cloned animals. [BMB reports 2011; 44(8): 535-540]
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alexander, C. M / 1996 / Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation / Deve
Edwards, J. L / 2003 / Cloning adult farm animals: a review of the possibilities and problems associated with somatic cell nuclear transfer / Am. J. Reprod. Immunol 50 : 113
Humpherys, D / 2001 / Epigenetic instability in ES cells and cloned mice / Science 293 : 95 ~ 97
Isaka, K / 2003 / Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts / Placenta 24 : 53 ~ 64
Jia, S, H / 2004 / Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental i
Edwards, J. L / 2003 / Cloning adult farm animals: a review of the possibilities and problems associated with somatic cell nuclear transfer / Am. J. Reprod. Immunol 50 : 113
Humpherys, D / 2001 / Epigenetic instability in ES cells and cloned mice / Science 293 : 95 ~ 97
Isaka, K / 2003 / Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts / Placenta 24 : 53 ~ 64
Jia, S, H / 2004 / Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental i
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