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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 577 - 588 (12page)
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초록· 키워드
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DNA methylation at CpG sites is an essential epigenetic mark that regulates gene expression during mammalian development and diseases. Methylome refers to the entire set of methylation modifications present in the whole genome. Over the last several years, an increasing number of reports on brain DNA methylome reported the association between aberrant methylation and the abnormalities in the expression of critical genes known to have critical roles during aging and neurodegenerative diseases. Consequently, the role of methylation in understanding neurodegenerative diseases has been under focus. This review outlines the current knowledge of the human brain DNA methylomes during aging and neurodegenerative diseases. We describe the differentially methylated genes from fetal stage to old age and their biological functions. Additionally, we summarize the key aspects and methylated genes identified from brain methylome studies on neurodegenerative diseases. The brain methylome studies could provide a basis for studying the functional aspects of neurodegenerative diseases.
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참고문헌 (98)
참고문헌 신청
Wyatt G / 1951 / Recognition and estimation of 5-methylcytosine in nucleic acids / Biochem J 48:581
Hotchkiss RD / 1948 / The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography / J Biol Chem 175:315~332
Bird AP / 1980 / DNA methylation and the frequency of CpG in animal DNA / Nucleic Acids Res 8:1499~1504
Illingworth RS / 2010 / Orphan CpG islands identify numerous conserved promoters in the mammalian genome / PLoS Genet 6:e1001134
Ladd-Acosta C / 2007 / DNA methylation signatures within the human brain / Am J Hum Genet 81:1304~1315
Hotchkiss RD / 1948 / The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography / J Biol Chem 175:315~332
Bird AP / 1980 / DNA methylation and the frequency of CpG in animal DNA / Nucleic Acids Res 8:1499~1504
Illingworth RS / 2010 / Orphan CpG islands identify numerous conserved promoters in the mammalian genome / PLoS Genet 6:e1001134
Ladd-Acosta C / 2007 / DNA methylation signatures within the human brain / Am J Hum Genet 81:1304~1315
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