지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Department of Neurology, Inje University, Ilsan Paik Hospital
B a c k g ro u n d: Clinical trials demonstrated that intravenous tissue plasminogen activator (t-PA) was safe and effective in hyperacute ischemic stroke. Our objective was to determine whether t-PA therapy could be used safely and effectively in a community-based university hospital. Methods: From April 2000 to July 2004, retrospective and prospective data of intravenous t-PA therapy were collected in Ilsan Paik Hospital. Efficacy was assessed by the improvement of National Institutes of Health Stroke Scale (NIHSS) by 4 or more points, the marked improvement (NIHSS decreased ≥10 points or a decrease to an NIHSS score of ≤3), and modified Rankin scale (mRS) at discharge. Safety was assessed by symptomatic intracranial hemorrhage and mortality. R e s u l t: Sixty-eight patients were treated with intravenous t-PA (mean age; 67±13, median NIHSS; 18). Only three (4%) patients were small-vessel occlusion. Time interval from onset to treatment was 151±40 minutes. Improvement of NIHSS by 4 or more points at discharge occurred in thirty-three patients (48%). Twenty-three patients (34%) showed marked improvement. According to mRS, 13% (9/68) of patients had no or minimal symptoms (mRS 0-1) and
19% (13/68) had mild to moderate disability (mRS 2-3), while 50% (34/68) remained dependent and 17% (12/68) died. Five patients (7.3%) had symptomatic intracranial hemorrhage. Three deaths were attributed to symptomatic intracranial hemorrhage. Conclusions: Intravenous t-PA therapy was safe in the setting of a community-based university hospital in spite of inferior efficacy compared to those of previous clinical trials. However, considerable number of patients showed marked improvement with t-PA therapy.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Simple Estimates of Symptomatic Intracranial Hemorrhage Risk and Outcome after Intravenous Thrombolysis Using Age and Stroke Severity
대한뇌졸중학회지
2017 .01
-
기계환기 적용 중 발생한 두개강내출혈 환자의 임상적 특성과 예후
Acute and Critical Care
2012 .01
-
Spontaneous Intracranial Hemorrhage in Children: Analysis of Clinical Characteristics
대한신경외과학회지
2005 .01
-
Imaging of Intracranial Hemorrhage
대한뇌졸중학회지
2017 .01
-
80세 이상 급성기 뇌졸중 환자에게 시행하는 정맥내 혈전용해치료: 단일 기관 예비연구
대한뇌졸중학회지
2010 .01
-
소아에서 사고에 의하지 않은 두개내 출혈의 임상적 고찰
Clinical and Experimental Pediatrics
2003 .01
-
자발성 두 개강내출혈의 전산화단층소견
대한방사선의학회지
1987 .01
-
정맥 혈전용해술과 관련된 뇌출혈에 대한 지혈치료 후 뇌경색이 악화된 증례
대한뇌졸중학회지
2011 .01
-
현장검안 시 외상성 머리안출혈 진단을 위한 근적외선 분광분석기의 유용성에 대한 고찰
대한법의학회지
2020 .01
-
시험관내허혈환경에서과립구성장인자의인간뇌피질에서유래된신경세포주의보호효과
대한뇌졸중학회지
2004 .01
-
소아 두부외상의 임상적 분석
대한신경외과학회지
2001 .01
-
근막 이완술을 이용한 파스 이완술에 관한 고찰
대한물리치료학회지(JKPT)
1999 .01
-
Are in-Hospital Delays Important Obstacles in Thrombolytic Therapy Following Acute Ischemic Stroke?
Journal of Clinical Neurology
2007 .01
-
Self-efficacy to Engage in Physical Activity and Overcome Barriers, Sedentary Behavior, and Their Relation to Body Mass Index Among Elderly Indonesians With Diabetes
예방의학회지
2019 .01
-
Intracranial Hemorrhage Identified in the Early Stage after Applying Extracorporeal Membrane Oxygenation to Support Cardiopulmonary Resuscitation
Acute and Critical Care
2014 .01
-
Angioplasty, Stenting and Other Potential Treatments of Atherosclerotic Stenosis of the Intracranial Arteries: Past, Present and Future
대한뇌졸중학회지
2017 .01
-
Development of Submacular Hemorrhage in Neovascular Age-related Macular Degeneration: Influence on Visual Prognosis in a Clinical Setting
Korean Journal of Ophthalmology
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0