지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 37 - 41 (5page)
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초록· 키워드
오류제보하기
Background/Aims: Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized form of eosinophilic esophagitis (EoE) that responds to PPI therapy. It remains unclear whether PPI-REE represents a subphenotype of gastroesophageal reflux disease, a subphenotype of EoE, or its own distinct entity. The aim was to evaluate the clinicopathologic features of PPI-REE. Methods: Six patients were diagnosed with PPI-REE based on symptoms, endoscopic abnormalities, esophageal eosinophilia with ≥15 eosinophils/high-power field, and a response to PPI treatment. Symptoms and endoscopic and pathological findings were evaluated. Results: The median follow-up duration was 12 months. Presenting symptoms included dysphagia, heartburn, chest pain, foreign body sensation, acid reflux, and sore throat. All patients had typical endoscopic findings of EoE such as esophageal rings, linear furrows, nodularity, and whitish plaques. Three patients had a concomitant allergic disorder, and one had reflux esophagitis. Four patients exhibited elevated serum IgE, and five had positive skin prick tests. All patients experienced symptomatic resolution within 4 weeks and histologic resolution within 8 weeks after starting PPI therapy. There was no symptomatic recurrence. Conclusions: PPI therapy induced rapid resolution of symptoms and eosinophil counts in patients with PPI-REE. Large-scale studies with long-term follow-up are warranted.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Prasad GA / 2007 / Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study / Am J Gastroenterol 102:2627~2632
Veerappan GR / 2009 / Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study / Clin Gastroenterol Hepatol 7:420~426
Dellon ES / 2013 / ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) / Am J Gastroenterol 108:679~692
Liacouras CA / 2011 / Eosinophilic esophagitis: updated consensus recommendations for children and adults / Allergy Clin Immunol 128:3~20
Rodrigo S / 2008 / High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults / Am J Gastroenterol 103:435~442
Veerappan GR / 2009 / Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study / Clin Gastroenterol Hepatol 7:420~426
Dellon ES / 2013 / ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) / Am J Gastroenterol 108:679~692
Liacouras CA / 2011 / Eosinophilic esophagitis: updated consensus recommendations for children and adults / Allergy Clin Immunol 128:3~20
Rodrigo S / 2008 / High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults / Am J Gastroenterol 103:435~442
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신장이식 환자에게 위장관계 증상 예방 목적으로 투여하는 Proton Pump Inhibitors (PPIs) 안전성 비교분석
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