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논문 기본 정보

자료유형
학술저널
저자정보
Suzuki Yugo (Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan) Ochiai Yorinari (Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan) Kikuchi Daisuke (Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan) Koseki Mako (Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan) Ohashi Kenichi (Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) Hoteya Shu (Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.4
발행연도
2024.7
수록면
632 - 641 (10page)
DOI
10.5009/gnl230398

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초록· 키워드

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Background/Aims: Asymptomatic esophageal eosinophilia (aEE), characterized by eosinophil infiltration in the esophagus without clinical symptoms, has been reported as a precursor of eosinophilic esophagitis (EoE). Nevertheless, no report exists on the long-term clinical course of the disease. Therefore, this study aimed to investigate the long-term clinical course of aEE over 5 years, including the symptomatic conversion rate and the effect of treatments. Methods: We reviewed 28 patients with aEE who had been followed up for over 5 years with endoscopic monitoring. The basal characteristics of patients were compared with those of 58 patients diagnosed with EoE during the same period. Patients’ clinicopathological findings were collected and examined. Results: No significant differences in basal characteristics and histopathological findings were observed between the patients with aEE and those with EoE. The median follow-up duration was 64 months. Among the 28 patients with aEE, seven were treated with proton pump inhibitor or potassium-competitive acid blocker and the remaining 21 opted for follow-up with no medication. Among the treated patients, six (85.7%) exhibited endoscopic and pathologic improvements. Among the cases followed up without medication, the findings worsened in two (9.5%), improved spontaneously in seven (33.3%), and were unchanged in 12 (57.1%), and three (14.3%) developed symptoms at a mean time of 40 months. Symptoms developed in cases where endoscopic and pathologic findings remained unchanged or worsened during follow-up. Conclusions: Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.

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