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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 38 - 46 (9page)
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The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations. CIMP-H CRCs arise in sessile or traditional serrated adenomas and thus tend to display the morphological characteristics of serrated adenomas, including epithelial serration, vesicular nuclei, and abundant cytoplasm. Both the frequent association of CIMP and poor prognosis and different responses of CRCs to adjuvant therapy depending on CIMP status indicate clinical implications. In this review, we present an overview of the literature documenting the relevant findings of CIMP-H CRCs and their relationships with the serrated neoplasia pathway.
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참고문헌 (25)
참고문헌 신청
Aaltonen LA / 1994 / Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients / Cancer Res 54 : 1645 ~ 1648
Ahn JB / 2011 / DNA methylation predicts recurrence from resected stage III proximal colon cancer / Cancer 117 : 1847 ~ 1854
Bae JM / 2013 / Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location / Br J Cancer 109 : 1004 ~ 1012
Bettington M / 2013 / The serrated pathway to colorectal carcinoma: current concepts and challenges / Histopathology 62 : 367 ~ 386
Bettington ML / 2015 / A clinicopathological and molecular analysis of 200 traditional serrated adenomas / Mod Pathol 28 : 414 ~ 427
Ahn JB / 2011 / DNA methylation predicts recurrence from resected stage III proximal colon cancer / Cancer 117 : 1847 ~ 1854
Bae JM / 2013 / Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location / Br J Cancer 109 : 1004 ~ 1012
Bettington M / 2013 / The serrated pathway to colorectal carcinoma: current concepts and challenges / Histopathology 62 : 367 ~ 386
Bettington ML / 2015 / A clinicopathological and molecular analysis of 200 traditional serrated adenomas / Mod Pathol 28 : 414 ~ 427
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