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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제4호
- 발행연도
- 2020.1
- 수록면
- 276 - 289 (14page)
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Here, we provide an up-to-date review of the histopathology and molecular pathology of serrated colorectal lesions. First, we introduce the updated contents of the 2019 World Health Organization classification for serrated lesions. The sessile serrated lesion (SSL) is a new diagnostic terminology that replaces sessile serrated adenoma and sessile serrated polyp. The diagnostic criteria for SSL were revised to require only one unequivocal distorted serrated crypt, which is sufficient for diagnosis. Unclassified serrated adenomas have been included as a new category of serrated lesions. Second, we review ongoing issues concerning the morphology of serrated lesions. Minor morphologic variants with distinct molecular features were recently defined, including serrated tubulovillous adenoma, mucin-rich variant of traditional serrated adenoma (TSA), and superficially serrated adenoma. In addition to intestinal dysplasia and serrated dysplasia, minimal deviation dysplasia and not otherwise specified dysplasia were newly suggested as dysplasia subtypes of SSLs. Third, we summarize the molecular features of serrated lesions. The critical determinant of CpG island methylation development in SSLs is patient age. Interestingly, there may be ethnic differences in BRAF/KRAS mutation frequencies in SSLs. The molecular pathogenesis of TSAs is divided into KRAS and BRAF mutation pathways. SSLs with MLH1 methylation can progress into favorable prognostic microsatellite instability-positive (MSI+)/CpG island methylator phenotype-positive (CIMP+) carcinomas, whereas MLH1-unmethylated SSLs and BRAF-mutated TSAs can be precursors of poor-prognostic MSI−/CIMP+ carcinomas. Finally, based on our recent data, we propose an algorithm for stratifying risk subgroups of non-dysplastic SSLs.
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참고문헌 (76)
참고문헌 신청
WHO Classification of Tumours Editorial Board / 2019 / WHO classification of tumors: digestive system tumours. 5th ed / International Agency for Research on Cancer
Bateman AC / 2015 / UK guidance for the pathological reporting of serrated lesions of the colorectum / J Clin Pathol 68:585~591
World Health Organization / 2010 / WHO classification of tumours of the digestive system / International Agency for Research on Cancer
Pai RK / 2019 / An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas / Mod Pathol 32:1390~1415
Rex DK / 2012 / Serrated lesions of the colorectum : review and recommendations from an expert panel / Am J Gastroenterol 107:1315~1329
Bateman AC / 2015 / UK guidance for the pathological reporting of serrated lesions of the colorectum / J Clin Pathol 68:585~591
World Health Organization / 2010 / WHO classification of tumours of the digestive system / International Agency for Research on Cancer
Pai RK / 2019 / An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas / Mod Pathol 32:1390~1415
Rex DK / 2012 / Serrated lesions of the colorectum : review and recommendations from an expert panel / Am J Gastroenterol 107:1315~1329
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