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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 235 - 238 (4page)
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초록· 키워드
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Conventional adenomas have historically been considered to be the only screening-relevant colorectal cancer (CRC) precursorlesion. The prevailing paradigm was that most CRCs arise along the chromosomal instability pathway, where adenomas accumulateincremental genetic alterations over time, leading eventually to malignancy. However, it is now recognized that this “conventional”pathway accounts for only about two-thirds of CRCs. The serrated pathway is responsible for most of the remainder, and is adisproportionate contributor to postcolonoscopy CRC. Hallmarks of the serrated pathway are mutations in the BRAF gene, high levelsof methylation of promoter CpG islands, and the sessile serrated polyp (SSP). Accumulating evidence shows that SSPs can be consideredadenoma-equivalent from the standpoint of CRC screening. SSPs have a higher prevalence than previously thought, and appear tohave a relatively long dwell time similar to that of conventional adenomas. In addition, SSPs, whether sporadic or as part of the serratedpolyposis syndrome, are associated with increased risk of synchronous and metachronous neoplasia. These features collectively supportthat SSPs are highly relevant to CRC prevention.
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참고문헌 (26)
참고문헌 신청
Snover DC / 2010 / WHO classification of tumours of the digestive system / Spinger-Verlag :120~126
Snover DC / 2011 / Update on the serrated pathway to colorectal carcinoma / Hum Pathol 42:1~10
Crockett SD / 2018 / Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial / Gut
Davenport JR / 2018 / Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps / Gut 67:456~465
Lash RH / 2010 / Sessile serrated adenomas : prevalence of dysplasia and carcinoma in 2139 patients / J Clin Pathol 63:681~686
Snover DC / 2011 / Update on the serrated pathway to colorectal carcinoma / Hum Pathol 42:1~10
Crockett SD / 2018 / Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial / Gut
Davenport JR / 2018 / Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps / Gut 67:456~465
Lash RH / 2010 / Sessile serrated adenomas : prevalence of dysplasia and carcinoma in 2139 patients / J Clin Pathol 63:681~686
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