지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 208 - 215 (8page)
이용수
초록· 키워드
오류제보하기
Purpose Hypermethylation of the CpG island of p16INK4a occurs in a significant proportion of colorectal cancer (CRC). We aimed to investigate its predictive role in CRC patients treated with 5-fluorouracil, leucovorin, irinotecan (FOLFIRI), and cetuximab.
Materials and Methods Pyrosequencing was used to identify KRAS mutation and hypermethylation of 6 CpG island loci (p16, p14, MINT1, MINT2, MINT31, and hMLH1) in DNA extracted from formalin-fixed paraffin-embedded specimens. Logistic regression and Cox regression were performed for analysis of the relation between methylation status of CpG island methylator phenotype (CIMP) markers including p16 and clinical outcome.
Results Hypermethylation of the p16 gene was detected in 14 of 49 patients (28.6%) and showed significant association with KRAS mutation (Fisher exact, p=0.01) and CIMP positivity (Fisher exact, p=0.002). Patients with p16-unmethylated tumors had significantly longer time to progression (TTP; median, 9.0 months vs. 3.5 months; log-rank, p=0.001) and overall sur- vival (median, 44.9 months vs. 16.4 months; log-rank, p=0.008) than those with p16-methy- lated tumors. Patients with both KRAS and p16 aberrancy (n=6) had markedly shortened TTP (median, 2.8 months) compared to those with either KRAS or p16 aberrancy (n=11; median, 8.6 months; p=0.021) or those with neither (n=32; median, 9.0 months; p < 0.0001). In multivariate analysis, KRAS mutation and p16 methylation showed inde- pendent association with shorter TTP (KRAS mutation: hazard ratio [HR], 3.21; p=0.017; p16 methylation: HR, 2.97; p=0.027).
Conclusion Hypermethylation of p16 was predictive of clinical outcome in metastatic CRC patients treated with cetuximab and FOLFIRI, irrespective of KRAS mutation.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Fearon ER / 1990 / A genetic model for colorectal tumorigenesis / Cell 61:759~767
Jass JR / 2007 / Classification of colorectal cancer based on correlation of clinical, morphological and molecular features / Histopathology 50:113~130
Kelley RK / 2011 / Biomarker use in colorectal cancer therapy / J Natl Compr Canc Netw 9:1293~1302
Schmoll HJ / 2012 / ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making / Ann Oncol 23:2479~2516
Van Cutsem E / 2011 / Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer : updated analysis of overall survival according to tumor KRAS and BRAF mutation status / J Clin Oncol 29:2011~2019
Jass JR / 2007 / Classification of colorectal cancer based on correlation of clinical, morphological and molecular features / Histopathology 50:113~130
Kelley RK / 2011 / Biomarker use in colorectal cancer therapy / J Natl Compr Canc Netw 9:1293~1302
Schmoll HJ / 2012 / ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making / Ann Oncol 23:2479~2516
Van Cutsem E / 2011 / Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer : updated analysis of overall survival according to tumor KRAS and BRAF mutation status / J Clin Oncol 29:2011~2019
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Correlation between RAS Test Results and Prognosis of Metastatic Colorectal Cancer Patients: a Report from Western Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Mutational analysis of KRAS and its clinical implications in cervical cancer patients
Journal of Gynecologic Oncology
2018 .01
-
Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Evaluation of KRAS Gene Mutations in Metastatic Colorectal Cancer Patients in Kermanshah Province
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Mutation Analysis of KRAS and BRAF Genes in Metastatic Colorectal Cancer: a First Large Scale Study from Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Magnetic Resonance-Based Texture Analysis Differentiating KRAS Mutation Status in Rectal Cancer
Cancer Research and Treatment
2020 .01
-
KRAS Mutation as a Biomarker for Survival in Patients with Non-Small Cell Lung Cancer, A Meta-Analysis of 12 Randomized Trials
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
EGFR targeting antibody of GC1118 effects in Colorectal cancer with KRAS mutation
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Detection of EGFR and KRAS Mutation by Pyrosequencing Analysis in Cytologic Samples of Non-Small Cell Lung Cancer
Journal of Korean Medical Science
2016 .01
-
CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer
Yonsei Medical Journal
2018 .01
-
Can the presence of KRAS mutations guide the type of liver resection during simultaneous resection of colorectal liver metastasis?
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .05
-
KRAS Mutation Test in Korean Patients with Colorectal Carcinomas: A Methodological Comparison between Sanger Sequencing and a Real-Time PCR-Based Assay
Journal of Pathology and Translational Medicine
2017 .01
-
Prognostic Role of KRAS mRNA Expression in Breast Cancer
Journal of Breast Cancer
2019 .01
-
Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The prognostic impact of primary tumor site and KRAS mutation after curative intent surgery for colorectal cancer with liver metastases
대한외과학회 학술대회 초록집
2019 .10
-
Can Serum be Used for Analyzing the KRASMutation Status in Patients with Advanced Colorectal Cancer?
Cancer Research and Treatment
2015 .01
-
CpG Island Methylator Phenotype-High Colorectal Cancers and Their Prognostic Implications and Relationships with the Serrated Neoplasia Pathway
Gut and Liver
2017 .01
-
A Phase 1b/2a Study of GC1118 with 5-Fluorouracil, Leucovorin and Irinotecan (FOLFIRI) in Patients with Recurrent or Metastatic Colorectal Cancer
Cancer Research and Treatment
2024 .04
-
Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
Cancer Research and Treatment
2022 .07
-
Multicenter Phase II Study of Oxaliplatin, Irinotecan, and S-1 as First-Line Treatment for Patients with Recurrent or Metastatic Biliary Tract Cancer
Cancer Research and Treatment
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0