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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.2
- 발행연도
- 2019.6
- 수록면
- 202 - 209 (8page)
- DOI
- 10.3746/pnf.2019.24.2.202
이용수
초록· 키워드
오류제보하기
Peptidoglycan (PGN) is a cell wall constituent in dental plaque bacteria that triggers inflammatory responses. PGN binds Toll-like receptors, leading to increases in prostaglandin E2 and interleukin-1β, which play crucial roles in the inflammatory response and tissue destruction. Dental surgery can give plaque bacteria access to blood circulation, thereby creating a risk of septic inflammation of the endocardium. Plant-derived flavonoids have been reported to reduce inflammatory cytokine secretion by host cells. In the present study, we investigated the effects of flavonoid myricetin on expression of cyclooxygenase 2 (COX-2) in the H9c2 cells treated with PGN from Streptococcus sanguinis, a bacterial constituent of dental plaque associated with infective endocarditis. Myricetin exposure resulted in dose-dependent suppression of PGN-induced COX-2 expression, diminished phosphorylation of p38, extracellular signal regulated kinase 1/2, and c-Jun N-terminal kinase, and reduced IκB-α degradation, consistent with decreased COX-2 activity. In conclusion, the aforementioned results suggest that myricetin is useful for moderating the inflammatory response in infective endocarditis.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (41)
참고문헌 신청
Bali EB / 2014 / Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro : comparison with oleuropein, hydroxytyrosol, and quercetin / Planta Med 80:984~992
Banks J / 2002 / Streptococcus sanguis secretes CD14-binding proteins that stimulate cytokine synthesis : a clue to the pathogenesis of infective(bacterial)endocarditis? / Microb Pathog 32:105~116
Chen BC / 2009 / Rac1 regulates peptidoglycan-induced nuclear factor-B activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway / Mol Immunol 46:1179~1188
Chi PL / 2011 / Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1 via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-B activity in human rheumatoid arthritis synovial fibroblasts / Arthritis Rheum 63:2905~2917
Cho ML / 2007 / Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/ CXCL8 in human rheumatoid synovial fibroblasts / Immunol Lett 108:121~128
Banks J / 2002 / Streptococcus sanguis secretes CD14-binding proteins that stimulate cytokine synthesis : a clue to the pathogenesis of infective(bacterial)endocarditis? / Microb Pathog 32:105~116
Chen BC / 2009 / Rac1 regulates peptidoglycan-induced nuclear factor-B activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway / Mol Immunol 46:1179~1188
Chi PL / 2011 / Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1 via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-B activity in human rheumatoid arthritis synovial fibroblasts / Arthritis Rheum 63:2905~2917
Cho ML / 2007 / Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/ CXCL8 in human rheumatoid synovial fibroblasts / Immunol Lett 108:121~128
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UCI(KEPA) : I410-ECN-0101-2019-594-000871001