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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 890 - 898 (9page)
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초록· 키워드
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The purpose of this paper is to investigate potential anti-inflammatory and anti-oxidant effects of Tenebrio molitor. Macrophage cell response by outside stimulation leads expression of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and trigger expression of genes which are affected by inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), resulting in formation of inflammatory factors like nitric oxide (NO) and Prostaglandin E2 (PGE2). Cell viability was determined by MTT assay. In order to investigate anti-inflammatory agents, the inhibitory effects on the production of lipopolysaccharide (LPS)-induced NO in RAW 264.7 cells were examined. T. Molitor significantly decreased the production of NO in a dose-dependent manner, and also reduced the expression of iNOS, a COX-2 protein. As a result, the levels of protein such as PGE2, iNOS, COX-2 and MARKs were significantly reduced compared to non-treated group in T. Molitor water extract (TDW) treated group. Also, antioxidant effect of T. Molitor were investigated using DPPH, ABTS+ and superoxide anion radical scavenging activity tests in cell-free system. Antioxidant activity of T. molitor was found low in the DPPH radical scavenging test while high in the ABTS+ and superoxide anion radical scavenging activity tests. These results show that TDW could be an effective anti-pro-inflammatory and anti-oxidant agent.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Wattenberg LW / 1985 / Chemoprevention of cancer / Cancer Res 45 : 1 ~ 8
[학술지(정기간행물)] - Brieskorn CH / 1964 / The structure of carnosol / J Org Chem 29 : 2293 ~ 2298
[학술지(정기간행물)] - Ding C / 2009 / Targeting IL-6 in the treatment of inflammatory and autoimmune diseases / Expert Opin Investig Drugs 18 : 1457 ~ 1466
[학술지(정기간행물)] - 정진부 / 2012 / Anti-Inflammatory Effects of Ethyl Acetate Fraction from Cnidium officinale Makino on LPS-Stimulated RAW 264.7 and THP-1 Cells / 한국자원식물학회지 25 (3) : 299 ~ 307
[학술지(정기간행물)] - Lee HJ / 2006 / In vitro anti-inflammatory and anti-oxidative effects of cinnamomum camphora extracts / J Ethnopharmacol 103 : 208 ~ 216
[학술지(정기간행물)] - Brieskorn CH / 1964 / The structure of carnosol / J Org Chem 29 : 2293 ~ 2298
[학술지(정기간행물)] - Ding C / 2009 / Targeting IL-6 in the treatment of inflammatory and autoimmune diseases / Expert Opin Investig Drugs 18 : 1457 ~ 1466
[학술지(정기간행물)] - 정진부 / 2012 / Anti-Inflammatory Effects of Ethyl Acetate Fraction from Cnidium officinale Makino on LPS-Stimulated RAW 264.7 and THP-1 Cells / 한국자원식물학회지 25 (3) : 299 ~ 307
[학술지(정기간행물)] - Lee HJ / 2006 / In vitro anti-inflammatory and anti-oxidative effects of cinnamomum camphora extracts / J Ethnopharmacol 103 : 208 ~ 216
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UCI(KEPA) : I410-ECN-0101-2018-059-003061441