지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 59 - 70 (12page)
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초록· 키워드
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The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (aVD3), is known to exert beneficial effects in the treatment of autoimmune diseases because of its immunosuppressive effects. However, clinical application of aVD3 remains limited because of the potential side effects, particularly hypercalcemia. Encapsulation of aVD3 within biodegradable nanoparticles (NPs) would enhance the delivery of aVD3 to antigen presenting cells, while preventing the potential systemic side effects of aVD3. In the present study, polymeric NPs containing ovalbumin (OVA) and aVD3 (NP[OVA+aVD3]) were prepared via the water-in-oil-in-water double emulsion solvent evaporation method, after which their immunomodulatory effects were examined. Bone marrow-derived immature dendritic cells (DCs) treated with NP(OVA+aVD3) did not mature into immunogenic DCs but were converted into tolerogenic DCs, which express low levels of co-stimulatory molecules and MHC class II molecules, produce lower levels of pro-inflammatory cytokines while increasing the production of IL-10 and TGF-β, and induce the generation of Tregs. Intravenous injection with NP(OVA+aVD3) markedly suppressed the generation of OVA-specific CTLs in mice. Furthermore, OVA-specific immune tolerance was induced in mice orally administered with NP(OVA+aVD3). These results show that biodegradable NPs encapsulating both antigen and aVD3 can effectively induce antigenspecific immune suppression.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
O'Brien MA / 2012 / Vitamin D and the immune system: beyond rickets / Vet J 194:27~33
Bscheider M / 2016 / Vitamin D immunoregulation through dendritic cells / Immunology 148:227~236
Jeffery LE / 2009 / 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 / J Immunol 183:5458~5467
Palmer MT / 2011 / Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cells / J Biol Chem 286:997~1004
Joshi S / 2011 / 1,25-dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A / Mol Cell Biol 31:3653~3669
Bscheider M / 2016 / Vitamin D immunoregulation through dendritic cells / Immunology 148:227~236
Jeffery LE / 2009 / 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 / J Immunol 183:5458~5467
Palmer MT / 2011 / Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cells / J Biol Chem 286:997~1004
Joshi S / 2011 / 1,25-dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A / Mol Cell Biol 31:3653~3669
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UCI(KEPA) : I410-ECN-0101-2019-517-000788633