지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 38 - 45 (8page)
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초록· 키워드
오류제보하기
Background: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma.
Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined.
Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVAsensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls.
Conclusion: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.
Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined.
Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVAsensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls.
Conclusion: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusions
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Jiao L / 2014 / Antioxidant activities of the oligosaccharides from the roots, flowers and leaves of Panax ginseng C.A. Meyer / Carbohydr Polym 106 : 293 ~ 298
2. [학술지(정기간행물)] - Mi-Young Song / 2014 / Infl uence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women / Journal of Ginseng Research 38 (2) : 106 ~ 115
3. [학술지(정기간행물)] - Choi JH / 2013 / Cultivated ginseng inhibits 2,4-dinitrochlorobenzene- induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-alpha/IFN-gamma-induced TARC activation in HaCaT cells / Food Chem Toxicol 56 : 195 ~ 203
4. [학술지(정기간행물)] - Ying Gui / 2014 / Effects of extrusion cooking on physicochemical properties of white and red ginseng (powder) / Journal of Ginseng Research 38 (2) : 146 ~ 153
5. [학술지(정기간행물)] - Zhang H / 2012 / Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/ MS-based metabolomics approach / J Pharm Biomed Anal 62 : 258 ~ 273
2. [학술지(정기간행물)] - Mi-Young Song / 2014 / Infl uence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women / Journal of Ginseng Research 38 (2) : 106 ~ 115
3. [학술지(정기간행물)] - Choi JH / 2013 / Cultivated ginseng inhibits 2,4-dinitrochlorobenzene- induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-alpha/IFN-gamma-induced TARC activation in HaCaT cells / Food Chem Toxicol 56 : 195 ~ 203
4. [학술지(정기간행물)] - Ying Gui / 2014 / Effects of extrusion cooking on physicochemical properties of white and red ginseng (powder) / Journal of Ginseng Research 38 (2) : 146 ~ 153
5. [학술지(정기간행물)] - Zhang H / 2012 / Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/ MS-based metabolomics approach / J Pharm Biomed Anal 62 : 258 ~ 273
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UCI(KEPA) : I410-ECN-0101-2018-524-001597540