지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.21 No.2
- 발행연도
- 2015.1
- 수록면
- 222 - 235 (14page)
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Background/Aims Enteric dysbiosis is a risk factor for dietary proteins-associated intestinal alterations, contributing to the development of food allergies and the symptomatology of functional gastrointestinal disorders, mainly irritable bowel syndrome (IBS). We explored if a dysbiotic-like state, simulated by intraperitoneal administration of bacterial lipopolysaccharides (LPS), facilitates the sensitization to a luminal antigen, ovalbumin (OVA), in rats. Methods Rats were exposed to oral OVA for 1 week, alone or with LPS. Thereafter, colonic histology, goblet cell density, mucosal eosinophils and mucosal mast cell (MMC) and connective tissue mast cell (CTMC) were evaluated. Colonic expression (real-time quantitative polymerase chain reaction) of interleukins, IFN-1 and integrins was assessed to determine local immune responses.Luminal and wall adhered microbiota were characterized by fluorescence in situ hybridization. Colonic contractility (in vitro) served to assess functional changes associated to OVA and/or LPS.Results Neither OVA nor LPS, alone or combined, lead to structural alterations, except for a reduced goblet cell density in OVA-LPStreated rats. MMC density was unaffected, while CTMC counts increased within the submucosa of OVA-LPS-treated animals. Marginal immune activation (IFN-1 up-regulation) was observed in OVA-LPS-treated rats. LPS induced a dysbiotic-like state characterized by decreased luminal bacterial counts, with a specific loss of clostridia. LPS facilitated Clostridium spp. wall adherence, an effect prevented by OVA. Colonic contractility was altered in OVA-LPS-treated animals, showing increased basal activity and enhanced motor responses to OVA. Conclusions Changes in gut microbiota and/or direct effects of LPS might enhance/facilitate local neuroimmune responses to food antigens leading to motor alterations similar to those observed in IBS.
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참고문헌 (45)
참고문헌 신청
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Ohman L / 2007 / New insights into the pathogenesis and pathophysiology of irritable bowel syndrome / Dig Liver Dis 39:201~215
Ringel Y / 2013 / Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome / Am J Physiol Gastrointest Liver Physiol 305:G529~G541
Park MI / 2006 / Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review / Neurogastroenterol Motil 18:595~607
Salonen A / 2010 / Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives / Microbiology 156(Pt 11):3205~3215
Ohman L / 2007 / New insights into the pathogenesis and pathophysiology of irritable bowel syndrome / Dig Liver Dis 39:201~215
Ringel Y / 2013 / Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome / Am J Physiol Gastrointest Liver Physiol 305:G529~G541
Park MI / 2006 / Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review / Neurogastroenterol Motil 18:595~607
Salonen A / 2010 / Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives / Microbiology 156(Pt 11):3205~3215
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