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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 114 - 121 (8page)
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Purpose: To evaluate the effect of anti-interleukin-33 (anti-IL-33) on a mouse model of ovalbumin (OVA)-induced acute kidney injury (AKI).
Methods: Twenty-four female BALB/c mice were assigned to 4 groups: group A (control, n=6) was administered sterile saline intraperitoneally (i.p.) and intranasally (i.n.); group B (allergic, n=6) was administered i.p./i.n. OVA challenge; group C (null treatment, n=6) was administered control IgG i.p. before OVA challenge; and group D (anti-IL-33, n=6) was pretreated with 3.6 μg of anti-IL-33 i.p. before every OVA challenge. The following were evaluated after sacrifice: serum blood urea nitrogen and creatinine levels, Kidney injury molecule-1 gene (Kim-1) and protein (KIM-1) expression in renal parenchyma, and expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phosphorylated endothelial NOS (p-eNOS), and phosphorylated AMP kinase (p-AMPK) proteins in renal parenchyma.
Results: After OVA injection and intranasal challenge, mice in groups B and C showed significant increases in the expression of Kim-1 at both the mRNA and protein levels. After anti-IL-33 treatment, mice in group D showed significant Kim-1 downregulation at the mRNA and protein levels. Group D also showed significantly lower COX-2 protein expression, marginally lesser iNOS expression than groups B and C, and p-eNOS and p-AMPK expression at baseline levels.
Conclusions: Kim-1 could be a useful marker for detecting early-stage renal injury in mouse models of OVA-induced AKI.
Further, anti-IL-33 might have beneficial effects on these mouse models.
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참고문헌 (34)
참고문헌 신청
Baekkevold ES / 2003 / Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules / Am J Pathol 163:69~79
Kurowska-Stolarska M / 2011 / Interleukin-33: a novel mediator with a role in distinct disease pathologies / J Intern Med 269:29~35
Smith DE / 2010 / IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma / Clin Exp Allergy 40:200~208
Lüthi AU / 2009 / Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases / Immunity 31:84~98
Tago K / 2001 / Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V / Biochem Biophys Res Commun 285:1377~1383
Kurowska-Stolarska M / 2011 / Interleukin-33: a novel mediator with a role in distinct disease pathologies / J Intern Med 269:29~35
Smith DE / 2010 / IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma / Clin Exp Allergy 40:200~208
Lüthi AU / 2009 / Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases / Immunity 31:84~98
Tago K / 2001 / Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V / Biochem Biophys Res Commun 285:1377~1383
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