지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The purpose of this study is to examine the effect of water and fermentation extracts of KMS (Kami-Mihudeongsikjang-tang) on AD (atopic dermatitis). Additionally, by applying the fermentation extracts of KMS at the first sensitization and latency period, I investgated whether it could prevent AD.
Methods: In this study, to test the effect and preventive efficacy of KMSs on AD. DNCB-induced BALB/c mice of AD model was used. Through histological observation, epidermis and dermis thickness, the infiltration of eoshiphils and mast cells in epidermis and dermis were examined. We measured the serum level of IgE and IL-6, TNF-alpha, and the expressions of NF-κB and MAPK protein. In order to examine the effect of KMSs on keratinocyte, HaCaT cells were treated TNF-alpha and IFN-gamma to induce an inflammatory response. The KMSs were applied at various concentration in the experimental group. We investigated TARC expression.
Results: The treatment groups were reduced epidermis and dermis thickness, inhibited the infiltration of eosinophils and mast cells, reduced the serum level of IL-6. Moreover, sfKMS group reduced serum level of TNF-alpha, inhibited the protein expressions of NF-κB and the phosphoryllation of ERK, JNK and p38. Especially sfKMS-pre group were reduced the serum level of IgE, show significant inhibition on the protein expression of NF-κB and the phosphoryllation of ERK, JNK and p38. In the experiment on HaCaT cells, sfKMS group were reduced expression of TARC.
Conclusions: These result suggest that wKMS and sfKMS was effective in the treament on AD, and sfKMS would prevent AD.
Methods: In this study, to test the effect and preventive efficacy of KMSs on AD. DNCB-induced BALB/c mice of AD model was used. Through histological observation, epidermis and dermis thickness, the infiltration of eoshiphils and mast cells in epidermis and dermis were examined. We measured the serum level of IgE and IL-6, TNF-alpha, and the expressions of NF-κB and MAPK protein. In order to examine the effect of KMSs on keratinocyte, HaCaT cells were treated TNF-alpha and IFN-gamma to induce an inflammatory response. The KMSs were applied at various concentration in the experimental group. We investigated TARC expression.
Results: The treatment groups were reduced epidermis and dermis thickness, inhibited the infiltration of eosinophils and mast cells, reduced the serum level of IL-6. Moreover, sfKMS group reduced serum level of TNF-alpha, inhibited the protein expressions of NF-κB and the phosphoryllation of ERK, JNK and p38. Especially sfKMS-pre group were reduced the serum level of IgE, show significant inhibition on the protein expression of NF-κB and the phosphoryllation of ERK, JNK and p38. In the experiment on HaCaT cells, sfKMS group were reduced expression of TARC.
Conclusions: These result suggest that wKMS and sfKMS was effective in the treament on AD, and sfKMS would prevent AD.
목차
서론
재료 및 방법
실험결과
고찰
결론
참고문헌
참고문헌 (33)
참고문헌 신청
Coca AF / 1923 / On the classification of the phenomena of hypersensitiveness / J Immunol 8:163~182
Nutten S / 2015 / Atopic dermatitis : global epidemiology and risk factors / Ann Nutr Metab 66(1):8~16
Lee YU / 2016 / Modulatory effects of PG102(Actinidia arguta)on inflammatory cytokine mRNA expression in canine atopic dermatitis / Thai J Vet Med 46(4):601~607
Marco M / 2017 / Health benefits of fermented foods : microbiota and beyond / Current Opinion in Biotechnology 44:94~102
엄영란 / 2010 / HPLC를 이용한 고체발효 당귀의 지표성분 분석 / 한국한의학연구원논문집 16(1):173~178
Nutten S / 2015 / Atopic dermatitis : global epidemiology and risk factors / Ann Nutr Metab 66(1):8~16
Lee YU / 2016 / Modulatory effects of PG102(Actinidia arguta)on inflammatory cytokine mRNA expression in canine atopic dermatitis / Thai J Vet Med 46(4):601~607
Marco M / 2017 / Health benefits of fermented foods : microbiota and beyond / Current Opinion in Biotechnology 44:94~102
엄영란 / 2010 / HPLC를 이용한 고체발효 당귀의 지표성분 분석 / 한국한의학연구원논문집 16(1):173~178
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계
Allergy Asthma & Respiratory Diseases
2015 .01
-
Molecular Mechanism of Atopic Dermatitis Induction Following Sensitization and Challenge with 2,4-Dinitrochlorobenzene in Mouse Skin Tissue
Toxicological Research
2018 .01
-
Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
Clinical and Experimental Pediatrics
2015 .01
-
Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin
Immune Network
2021 .06
-
아토피피부염 동물 병태 모델에서 아토탕의 개선효과
대한본초학회지(본초분과학회지)
2016 .01
-
From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis
Immune Network
2018 .12
-
아토피 피부염 환아의 정신 건강 분석 및 아토피 피부염 교육을 통한 인식, 인지도 개선에 대한 고찰
한방안이비인후피부과학회지
2017 .01
-
Oral administration of D-galactose ameliorates DNCB-induced atopic dermatitis mouse model by modulation of gut microbiota
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Improvement effect of blackberry extract in atopic dermatitis mouse model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Natural History and Risk Factors of Atopic Dermatitis in Children
Allergy, Asthma & Immunology Research
2015 .01
-
The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice
대한의생명과학회지
2017 .12
-
Noninvasive Detection of Specific Diagnostic Biomarkers for Atopic Dermatitis
대한의생명과학회지
2019 .03
-
한국 소아 아토피피부염의 연구 현황과 과제
Allergy Asthma & Respiratory Diseases
2018 .09
-
Polyphenol-rich Sargassum horneri alleviates atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th-2 mediated cytokine IL-13
한국실험동물학회 학술발표대회 논문집
2021 .07
-
A Family-Engaged Educational Program for Atopic Dermatitis: A Seven-Year, Multicenter Experience in Daegu-Gyeongbuk, South Korea
Annals of Dermatology
2015 .01
-
Saccharina japonica Attenuates the Allergic Inflammation in vivo and in vitro
대한의생명과학회지
2022 .12
-
아토피피부염 치료 실태에 관한 다기관 설문조사
Allergy Asthma & Respiratory Diseases
2016 .01
-
황련 추출물의 아토피피부염 유발 생쥐에서 피부손상 완화 효과
동의생리병리학회지
2019 .01
-
2,4-Dinitrochlorobenzene으로 유도된 BALB/c 마우스에서 Black currant seed oil의 아토피성 피부염 억제 효과
동의생리병리학회지
2015 .01
-
Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
Immune Network
2018 .04
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-519-000766628