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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 61 - 67 (7page)
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초록· 키워드
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Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine milieu required for accurate reproduction of AD-related gene expression profile in vitro, we evaluated the expression pattern of CCL22, CCL17, IL5, IL13, IL33, IL25, TSLP, FLG, and LOR in human lesional AD skin and cytokine-stimulated HaCaT cells. An increase in Th2 mediators (IL5, IL13, CCL22, CCL17, IL25, IL33, and TSLP) and a decrease in genes related to cornified cell envelope (filaggrin and loricrin) were observed in human AD lesions. Innate (tumor necrosis factor-α) and/or Th1/Th2 adaptive cytokines (interferon-γ/IL-4) were required for inducing these inflammatory changes in HaCaT cells, implying that a complex network of innate, Th1, and Th2 cytokines drives AD-like changes. Therefore, stimulation with various combinations of cytokines, beyond Th2 polarization, is necessary when HaCaT cell line is used to study genetic changes implicated in AD pathogenesis.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Hamid Q / 1996 / In vivo expression of IL-12 and IL-13 in atopic dermatitis / J Allergy Clin Immunol 98:225~231
Leung DY / 1999 / Pathogenesis of atopic dermatitis / J Allergy Clin Immunol 104:S99~S108
Bartemes KR / 2012 / Dynamic role of epithelium-derived cytokines in asthma / Clin Immunol 143:222~235
Salimi M / 2013 / A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis / J Exp Med 210:2939~2950
Grewe M / 1994 / Lesional expression of interferon-gamma in atopic eczema / Lancet 343:25~26
Leung DY / 1999 / Pathogenesis of atopic dermatitis / J Allergy Clin Immunol 104:S99~S108
Bartemes KR / 2012 / Dynamic role of epithelium-derived cytokines in asthma / Clin Immunol 143:222~235
Salimi M / 2013 / A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis / J Exp Med 210:2939~2950
Grewe M / 1994 / Lesional expression of interferon-gamma in atopic eczema / Lancet 343:25~26
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UCI(KEPA) : I410-ECN-0101-2018-517-002013097