지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 233 - 239 (7page)
- DOI
- 10.7783/KJMCS.2018.26.3.233
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초록· 키워드
오류제보하기
Background: Inflammation plays an important role in various diseases, including ulcerative colitis, Behcet’s disease, and rheumatoid arthritis. In this study, we investigated the anti-inflammatory effects of Morus alba L. extracts obtained using different extraction methods (water extraction or high temperature extraction) on RAW264.7 cells.
Methods and Results: Extracts from the central part (including the heartwood, sapwood, cambiun, and phloem) and bark (including the periderm and cortex) of Morus alba L. were obtained using either water or high temperature extraction. The following extract were obtained: MA1, water extract from the central part of Morus alba L., MA2, high temperature extract from the central part of Morus alba L., MA3, water extract from the bark of Morus alba L., and MA4, high temperature extract from the bark of Morus alba L. None of these extracts was observed to be cytotoxic to RAW264.7 cells. The MA2 extract reduced the production of LPS-induced NO (nitric oxide), PGE2 (prostaglandin E2), TNF-α, IL-6, and IL-1β production in LPS-stimulated RAW264.7 cells.
Conclusions: These results indicated that the inflammatory response was moderated by MA2. Treatment with MA2 could be used as a natural medicine for treating diseases involving inflammation. However, further experiments are required to determine how the high temperature extraction method alters the active ingredients in the extract and influences the anti-inflammatory effects of Morus alba L..
Methods and Results: Extracts from the central part (including the heartwood, sapwood, cambiun, and phloem) and bark (including the periderm and cortex) of Morus alba L. were obtained using either water or high temperature extraction. The following extract were obtained: MA1, water extract from the central part of Morus alba L., MA2, high temperature extract from the central part of Morus alba L., MA3, water extract from the bark of Morus alba L., and MA4, high temperature extract from the bark of Morus alba L. None of these extracts was observed to be cytotoxic to RAW264.7 cells. The MA2 extract reduced the production of LPS-induced NO (nitric oxide), PGE2 (prostaglandin E2), TNF-α, IL-6, and IL-1β production in LPS-stimulated RAW264.7 cells.
Conclusions: These results indicated that the inflammatory response was moderated by MA2. Treatment with MA2 could be used as a natural medicine for treating diseases involving inflammation. However, further experiments are required to determine how the high temperature extraction method alters the active ingredients in the extract and influences the anti-inflammatory effects of Morus alba L..
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (31)
참고문헌 신청
Bergeron C / 2005 / Comparison of the chemical composition of extracts from Scutellaria lateriflora using accelerated solvent extraction and supercritical fluid extraction versus standard hot water or 70% ethanol extraction / Journal of Agricultural and Food Chemistry 53:3076~3080
Bradley JR / 2008 / TNF-mediated inflammatory disease / Journal of Pathology 214:149~160
Guslandi M / 1998 / Nitric oxide and inflammatory bowel disease / European Journal of Clinical Investigation 28:904~907
임도연 / 2014 / 화피의 휘발성 향기성분 조성과 주요성분인 Benzaldehyde의 생리활성 / 아시안뷰티화장품학술지 12(2):155~162
지종대 / 2004 / Prostaglandin E2: 면역 및 염증반응에서의 역할 / 대한류마티스학회지 11(4):307~316
Bradley JR / 2008 / TNF-mediated inflammatory disease / Journal of Pathology 214:149~160
Guslandi M / 1998 / Nitric oxide and inflammatory bowel disease / European Journal of Clinical Investigation 28:904~907
임도연 / 2014 / 화피의 휘발성 향기성분 조성과 주요성분인 Benzaldehyde의 생리활성 / 아시안뷰티화장품학술지 12(2):155~162
지종대 / 2004 / Prostaglandin E2: 면역 및 염증반응에서의 역할 / 대한류마티스학회지 11(4):307~316
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