지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.11
- 수록면
- 277 - 282 (6page)
- DOI
- 10.17519/apiculture.2018.11.33.4.277
이용수
초록· 키워드
오류제보하기
Ethanol extracted propolis (EEP) was mixed with honey (honeypolis) to dissolve well in water and in vitro skin irritation test was conducted. In vitro method is designed to predict and classify the skin irritation potential of a chemical by assessment of its effect on EpiDerm<SUP>TM</SUP>, a reconstituted threedimensional human epidermis model. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity measured by formazan production from MTT after a 60 min exposure period. In this study under the given conditions honeypolis showed no irritant effects. Honeypolis meets acceptance criteria if: mean absolute OD 570 nm of the three negative control tissues is ≥0.8 and ≤2.8, mean relative tissue viability of the three positive control tissues is ≤ 20%, standard deviation of relative tissue viability obtained from each three concurrently tested tissues is ≤ 18%. Honeypolis is therefore classified as “non-irritant” in accordance with UN GHS “No Category”.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
LITERATURE CITED
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Bors, W. / 1990 / Flavonoids as antioxidants: determination of radicalscavenging efficiencies / Meth. Enzymol 186 : 343 ~ 355
[학술지(정기간행물)] - Burdock, G. A. / 1998 / Review of the biological properties and toxicity of bee propolis / Food Chem. Toxicol 36 : 347 ~ 363
[학술지(정기간행물)] - Cotovio, J. / 2005 / The in vitro acute skin irritation of chemicals: optimization of the EpiSkin prediction model within the framework of the ECVAM validation process / ATLA 33 : 329 ~ 349
[학술지(정기간행물)] - Draize, J. H. / 1944 / Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes / Journal of Pharmacology and Experimental Therapeutics 82 : 337 ~ 390
[기타자료] - EC / 2008 / EC. 2008. Regulation (EC) No. 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 / Official Journal of the European Union : 1 ~ 1355
[학술지(정기간행물)] - Burdock, G. A. / 1998 / Review of the biological properties and toxicity of bee propolis / Food Chem. Toxicol 36 : 347 ~ 363
[학술지(정기간행물)] - Cotovio, J. / 2005 / The in vitro acute skin irritation of chemicals: optimization of the EpiSkin prediction model within the framework of the ECVAM validation process / ATLA 33 : 329 ~ 349
[학술지(정기간행물)] - Draize, J. H. / 1944 / Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes / Journal of Pharmacology and Experimental Therapeutics 82 : 337 ~ 390
[기타자료] - EC / 2008 / EC. 2008. Regulation (EC) No. 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 / Official Journal of the European Union : 1 ~ 1355
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UCI(KEPA) : I410-ECN-0101-2019-527-000167736