지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.95 No.6
- 발행연도
- 2018.12
- 수록면
- 303 - 311 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: OncoHepa test is a multigene expression profile test developed for assessment of hepatocellular carcinoma (HCC) prognosis. Multiplication of α-FP, des-γ-carboxy prothrombin (DCP) and tumor volume (TV) gives the α-FP-DCP-volume (ADV) score, which is also developed for assessment of HCC prognosis.
Methods: The predictive powers of OncoHepa test and ADV score were validated in 35 patients who underwent curative hepatic resection for naïve solitary HCCs ≤5 cm.
Results: Median tumor diameter was 3.0 cm. Tumor recurrence and patient survival rates were 28.6% and 100% at 1 year, 48.6% and 82.9% at 3 years, and 54.3% and 71.4% at 5 years, respectively. The site of first tumor recurrence was the remnant liver in 18, lung in 1, and the peritoneum in 1. All patients with HCC recurrence received locoregional treatment. OncoHepa test showed marginal prognostic significance for tumor recurrence and patient survival. ADV score at 4log also showed marginal prognostic difference with respect to tumor recurrence and patient survival. Combination of these 2 tests resulted in greater prognostic significance for both tumor recurrence (P = 0.046) and patient survival (P = 0.048).
Conclusion: Both OncoHepa test and ADV score have considerably strong prognostic power, thus individual and combined findings of OncoHepa test and ADV score will be helpful to guide postresection surveillance in patients with solitary HCCs ≤5 cm.
Methods: The predictive powers of OncoHepa test and ADV score were validated in 35 patients who underwent curative hepatic resection for naïve solitary HCCs ≤5 cm.
Results: Median tumor diameter was 3.0 cm. Tumor recurrence and patient survival rates were 28.6% and 100% at 1 year, 48.6% and 82.9% at 3 years, and 54.3% and 71.4% at 5 years, respectively. The site of first tumor recurrence was the remnant liver in 18, lung in 1, and the peritoneum in 1. All patients with HCC recurrence received locoregional treatment. OncoHepa test showed marginal prognostic significance for tumor recurrence and patient survival. ADV score at 4log also showed marginal prognostic difference with respect to tumor recurrence and patient survival. Combination of these 2 tests resulted in greater prognostic significance for both tumor recurrence (P = 0.046) and patient survival (P = 0.048).
Conclusion: Both OncoHepa test and ADV score have considerably strong prognostic power, thus individual and combined findings of OncoHepa test and ADV score will be helpful to guide postresection surveillance in patients with solitary HCCs ≤5 cm.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Forner A / 2012 / Hepatocellular carcinoma / Lancet 379 : 1245 ~ 1255
[학술지(정기간행물)] - Hwang S / 2015 / The impact of tumor size on long-term survival outcomes after resection of solitary hepatocellular carcinoma : single-institution experience with 2558 patients / J Gastrointest Surg 19 : 1281 ~ 1290
[학술지(정기간행물)] - Hwang S / 2016 / Multiplication of tumor volume by two tumor markers is a post-resection prognostic predictor for solitary hepatocellular carcinoma / J Gastrointest Surg 20 : 1807 ~ 1820
[학술지(정기간행물)] - Shindoh J / 2013 / Microvascular invasion does not predict longterm survival in hepatocellular carcinoma up to 2 cm : reappraisal of the staging system for solitary tumors / Ann Surg Oncol 20 : 1223 ~ 1229
[학술지(정기간행물)] - Shindoh J / 2013 / Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma / HPB(Oxford) 15 : 31 ~ 39
[학술지(정기간행물)] - Hwang S / 2015 / The impact of tumor size on long-term survival outcomes after resection of solitary hepatocellular carcinoma : single-institution experience with 2558 patients / J Gastrointest Surg 19 : 1281 ~ 1290
[학술지(정기간행물)] - Hwang S / 2016 / Multiplication of tumor volume by two tumor markers is a post-resection prognostic predictor for solitary hepatocellular carcinoma / J Gastrointest Surg 20 : 1807 ~ 1820
[학술지(정기간행물)] - Shindoh J / 2013 / Microvascular invasion does not predict longterm survival in hepatocellular carcinoma up to 2 cm : reappraisal of the staging system for solitary tumors / Ann Surg Oncol 20 : 1223 ~ 1229
[학술지(정기간행물)] - Shindoh J / 2013 / Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma / HPB(Oxford) 15 : 31 ~ 39
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UCI(KEPA) : I410-ECN-0101-2019-514-000192483