지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.5
- 발행연도
- 2020.5
- 수록면
- 235 - 246 (12page)
이용수
초록· 키워드
오류제보하기
Purpose: We aimed to validate the prognostic predictive power of ADV score (α-FP-des-γ-carboxyprothrombin [DCP]-tumor volume [TV] score, calculated as α-FP [ng/mL] × DCP [mAU/mL] × TV [mL] and expressed in log<SUB>10</SUB>) for predicting patient survival after resection of hepatocellular carcinoma (HCC).
Methods: This study included 1,390 patients with HCC registered in the Korea Liver Cancer Registry. Patients underwent hepatic resection between 2008 and 2012 and were followed up until December 2016. They were divided into 4 groups according to the number of tumors and preoperative treatment.
Results: There was no significant correlation among α-FP, DCP, and TV values (r<SUP>2</SUP> ≤ 0.04, P < 0.001). In group 1 with single treatment-naive tumor (n = 1,154), patient stratification with postoperative ADV 1log-interval and cutoffs of 5log, 7log, and 10log showed great prognostic contrast (P < 0.001). In group 2 with multiple treatment-naive tumors (n = 170), patient stratification with postoperative ADV 1log-interval and above-mentioned 3 cutoffs also showed great prognostic contrast (P < 0.001). In group 3 (n = 50) and group 4 (n = 16) with preoperative-treated tumors, patient stratification with postoperative ADV 1log-interval and above-mentioned 3 cutoffs showed noticeable prognostic contrast (P ≤ 0.031). Preoperative ADV score based on preoperative findings also showed great prognostic contrast in 1,106 patients preoperatively diagnosed as having single treatment-naive tumor (P < 0.001). Confining patients to tumor-node-metastasis stages I and II (n = 1,072) as well as Barcelona Clinic Liver Cancer stage 0 and A (n = 862), postoperative ADV cutoffs showed further prognostic stratification.
Conclusion: This validation study strongly suggests that ADV score is an integrated surrogate marker for postresection prognosis in patients with HCC.
Methods: This study included 1,390 patients with HCC registered in the Korea Liver Cancer Registry. Patients underwent hepatic resection between 2008 and 2012 and were followed up until December 2016. They were divided into 4 groups according to the number of tumors and preoperative treatment.
Results: There was no significant correlation among α-FP, DCP, and TV values (r<SUP>2</SUP> ≤ 0.04, P < 0.001). In group 1 with single treatment-naive tumor (n = 1,154), patient stratification with postoperative ADV 1log-interval and cutoffs of 5log, 7log, and 10log showed great prognostic contrast (P < 0.001). In group 2 with multiple treatment-naive tumors (n = 170), patient stratification with postoperative ADV 1log-interval and above-mentioned 3 cutoffs also showed great prognostic contrast (P < 0.001). In group 3 (n = 50) and group 4 (n = 16) with preoperative-treated tumors, patient stratification with postoperative ADV 1log-interval and above-mentioned 3 cutoffs showed noticeable prognostic contrast (P ≤ 0.031). Preoperative ADV score based on preoperative findings also showed great prognostic contrast in 1,106 patients preoperatively diagnosed as having single treatment-naive tumor (P < 0.001). Confining patients to tumor-node-metastasis stages I and II (n = 1,072) as well as Barcelona Clinic Liver Cancer stage 0 and A (n = 862), postoperative ADV cutoffs showed further prognostic stratification.
Conclusion: This validation study strongly suggests that ADV score is an integrated surrogate marker for postresection prognosis in patients with HCC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Hwang S / 2015 / The impact of tumor size on long-term survival outcomes after resection of solitary hepatocellular carcinoma : single-institution experience with 2558 patients / J Gastrointest Surg 19:1281~1290
Hwang S / 2016 / Multiplication of tumor volume by two tumor markers is a post-resection prognostic predictor for solitary hepatocellular carcinoma / J Gastrointest Surg 20:1807~1820
Jung DH / 2019 / Small hepatocellular carcinoma with low tumor marker expression benefits more from anatomical resection than tumors with aggressive biology / Ann Surg 269:511~519
Hwang S / 2018 / Prognostic prediction models for resection of large hepatocellular carcinoma : a Korean multicenter study / World J Surg 42:2579~2591
Korean Association for the Study of the Liver / 2016 / KASL clinical practice guidelines:management of chronic hepatitis B / Clin Mol Hepatol 22:18~75
Hwang S / 2016 / Multiplication of tumor volume by two tumor markers is a post-resection prognostic predictor for solitary hepatocellular carcinoma / J Gastrointest Surg 20:1807~1820
Jung DH / 2019 / Small hepatocellular carcinoma with low tumor marker expression benefits more from anatomical resection than tumors with aggressive biology / Ann Surg 269:511~519
Hwang S / 2018 / Prognostic prediction models for resection of large hepatocellular carcinoma : a Korean multicenter study / World J Surg 42:2579~2591
Korean Association for the Study of the Liver / 2016 / KASL clinical practice guidelines:management of chronic hepatitis B / Clin Mol Hepatol 22:18~75
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