지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 316 - 325 (10page)
이용수
초록· 키워드
오류제보하기
Background: Ginseng essence (GE) is a formulation comprising four medicinal and edible herbs including ginseng (Panax ginseng), American ginseng (Panax quinquefolius), lotus seed (Nelumbo nucifera), and lily bulb (Lilium longiflorum). This study was aimed at investigating the hepatoprotective effect of GE against carbon tetrachloride (CCl₄)-induced liver injury in rats.
Methods: We treated Wistar rats daily with low, medium, and high [0.625 g/kg body weight (bw), 1.25 g/kg bw, and 3.125 g/kg bw, respectively] doses of GE for 9 wk. After the 1<SUP>st</SUP> wk of treatment, rats were administered 20% CCl₄ (1.5 mL/kg bw) two times a week to induce liver damage until the treatment ended.
Results: Serum biochemical analysis indicated that GE ameliorated the elevation of aspartate aminotransferase and alanine aminotransferase and albumin decline in CCl₄-treated rats. Moreover, CCl₄-induced accumulation of hepatic total cholesterol and triglyceride was inhibited. The hepatoprotective effects of GE involved enhancing the hepatic antioxidant defense system including glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, superoxide dismutase, and catalase. In addition, histological analysis using hematoxylin and eosin and Masson’s trichrome staining showed that GE inhibited CCl₄-induced hepatic inflammation and fibrosis. Furthermore, immunohistochemical staining of alpha-smooth muscle actin indicated that CCl₄-triggered activation of hepatic stellate cells was reduced.
Conclusion: These findings demonstrate that GE improves CCl₄-induced liver inflammation and fibrosis by attenuating oxidative stress. Therefore, GE could be a promising hepatoprotective herbal formulation for future development of phytotherapy.
Methods: We treated Wistar rats daily with low, medium, and high [0.625 g/kg body weight (bw), 1.25 g/kg bw, and 3.125 g/kg bw, respectively] doses of GE for 9 wk. After the 1<SUP>st</SUP> wk of treatment, rats were administered 20% CCl₄ (1.5 mL/kg bw) two times a week to induce liver damage until the treatment ended.
Results: Serum biochemical analysis indicated that GE ameliorated the elevation of aspartate aminotransferase and alanine aminotransferase and albumin decline in CCl₄-treated rats. Moreover, CCl₄-induced accumulation of hepatic total cholesterol and triglyceride was inhibited. The hepatoprotective effects of GE involved enhancing the hepatic antioxidant defense system including glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, superoxide dismutase, and catalase. In addition, histological analysis using hematoxylin and eosin and Masson’s trichrome staining showed that GE inhibited CCl₄-induced hepatic inflammation and fibrosis. Furthermore, immunohistochemical staining of alpha-smooth muscle actin indicated that CCl₄-triggered activation of hepatic stellate cells was reduced.
Conclusion: These findings demonstrate that GE improves CCl₄-induced liver inflammation and fibrosis by attenuating oxidative stress. Therefore, GE could be a promising hepatoprotective herbal formulation for future development of phytotherapy.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (49)
참고문헌 신청
[단행본] - Ministry of Health and Welfare / 2015 / 2014 Statistics of causes of death / Department of Statistics
[학술지(정기간행물)] - Dey A / 2013 / The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver / Food Funct 4 : 1148 ~ 1184
[학술지(정기간행물)] - Chowdhury MR / 2015 / Supplementation of Citrus maxima peel powder prevented oxidative stress, fibrosis, and hepatic damage in carbon tetrachloride (CCl4) treated rats / Evid Based Complement Alternat Med 2015 : 598179 ~
[학술지(정기간행물)] - Ucar F / 2013 / The relationship between oxidative stress and nonalcoholic fatty liver disease : its effects on the development of nonalcoholic steatohepatitis / Redox Rep 18 : 127 ~ 133
[학술지(정기간행물)] - Valko M / 2007 / Free radicals and antioxidants in normal physiological functions and human disease / Int J Biochem Cell Biol 39 : 44 ~ 84
[학술지(정기간행물)] - Dey A / 2013 / The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver / Food Funct 4 : 1148 ~ 1184
[학술지(정기간행물)] - Chowdhury MR / 2015 / Supplementation of Citrus maxima peel powder prevented oxidative stress, fibrosis, and hepatic damage in carbon tetrachloride (CCl4) treated rats / Evid Based Complement Alternat Med 2015 : 598179 ~
[학술지(정기간행물)] - Ucar F / 2013 / The relationship between oxidative stress and nonalcoholic fatty liver disease : its effects on the development of nonalcoholic steatohepatitis / Redox Rep 18 : 127 ~ 133
[학술지(정기간행물)] - Valko M / 2007 / Free radicals and antioxidants in normal physiological functions and human disease / Int J Biochem Cell Biol 39 : 44 ~ 84
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatoprotective effect of fermented black radish (Raphanus sativus L. var niger) in CCl4 induced liver injury in rats
예방수의학회지
2017 .12
-
Effects of intraperitoneal injection of magnetic graphene oxide on the improvement of acute liver injury induced by CCl4
생체재료학회지
2020 .01
-
족삼리 전침자극이 Carbon Tetrachloride 장기투여로 유발된 흰쥐의 만성 간손상에 미치는 영향
Korean Journal of Acupuncture
2015 .01
-
Carbon tetrachloride (CCl4)-induced liver fibrosis through activation of hepatic stellate cells by activation of RelA/p65 and alpha‐smooth muscle actin in mice
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
Journal of Pathology and Translational Medicine
2016 .01
-
Hepatoprotective effects of Allyl isothiocyanate in CCl4-induced hepatic damage in rats
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis
Yonsei Medical Journal
2015 .01
-
Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
Endocrinology and Metabolism
2021 .01
-
Differential hepatotoxicity of carbon tetrachloride in weaning and adult mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Expression of Chemokine CCL28 in Ulcerative Colitis Patients
Gut and Liver
2021 .01
-
Nuclear factor erythroid 2-related factor 2 활성화를 통한 해간전(解肝煎)의 간세포 보호 효능 및 분자기전을 활용한 해간전(解肝煎) 구성 약물의 최적화 연구
대한한의학방제학회지
2018 .01
-
Role of RelA/p65 and α-smooth muscle actin of activated hepatic stellate cell in carbon-tetrachloride-induced liver cirrhosis
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Hepatoprotective effect of both aqueous extracted and fermented black radish (Raphanus sativus L. var niger) in CCl4 induced liver injury in rats by attenuating oxidative stress
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Protective Effect of Polydeoxyribonucleotide Against CCl4-Induced Acute Liver Injury in Mice
International Neurourology Journal
2020 .01
-
CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
Cancer Research and Treatment
2015 .01
-
Serum CCL11 Levels in Benign Prostatic Hyperplasia and Prostate Cancer
Urogenital Tract Infection
2016 .01
-
Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes
Annals of Dermatology
2015 .01
-
Hepatoprotective effects of catechin in carbon tetrachloride-induced hepatic damage in rats
한국실험동물학회 학술발표대회 논문집
2022 .07
-
The expression of KAP3K7 regulates the susceptibility to steatosis-associated liver injury and fibrosis
한국실험동물학회 학술발표대회 논문집
2021 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-524-001599019