지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 312 - 319 (8page)
이용수
초록· 키워드
오류제보하기
Background: Previous studies have shown that both ginseng root and ginseng berry exhibit antiobesity and antidiabetic effects. However, a direct comparison of the efficacy and mechanisms between the root and the berry after oral administration remains to be illuminated.
Methods: In this study, we observed the effects of fermented ginseng root (FGR) and fermented ginseng berry (FGB) on obesity and lipid metabolism in high-fat diet induced obese mice.
Results: FGR and FGB significantly inhibited the activity of pancreatic lipase in vitro. Both FGR and FGB significantly suppressed weight gain and excess food intake and improved hypercholesterolemia and fatty liver, while only FGR significantly attenuated hyperglycemia and insulin resistance. Both FGR and FGB significantly inhibited the mRNA expression of Ldlr and Acsl1 while FGR also significantly inhibited expression of Cebpa and Dgat2 in liver. FGR significantly decreased the epididymal fat weight of mice while FGB significantly inhibited the mRNA expression of genes Cebpa, Fas, Hsl, Il1b, and Il6 in adipose tissue.
Conclusion: Saponin from both FGR and FGB had a beneficial effect on high-fat diet-induced obesity. Compared to FGB, FGR exhibited more potent antihyperglycemic and antiobesity effect. However, only FGB significantly inhibited mRNA expression of inflammatory markers such as interleukins 1β and 6 in adipose tissue.
Methods: In this study, we observed the effects of fermented ginseng root (FGR) and fermented ginseng berry (FGB) on obesity and lipid metabolism in high-fat diet induced obese mice.
Results: FGR and FGB significantly inhibited the activity of pancreatic lipase in vitro. Both FGR and FGB significantly suppressed weight gain and excess food intake and improved hypercholesterolemia and fatty liver, while only FGR significantly attenuated hyperglycemia and insulin resistance. Both FGR and FGB significantly inhibited the mRNA expression of Ldlr and Acsl1 while FGR also significantly inhibited expression of Cebpa and Dgat2 in liver. FGR significantly decreased the epididymal fat weight of mice while FGB significantly inhibited the mRNA expression of genes Cebpa, Fas, Hsl, Il1b, and Il6 in adipose tissue.
Conclusion: Saponin from both FGR and FGB had a beneficial effect on high-fat diet-induced obesity. Compared to FGB, FGR exhibited more potent antihyperglycemic and antiobesity effect. However, only FGB significantly inhibited mRNA expression of inflammatory markers such as interleukins 1β and 6 in adipose tissue.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (35)
참고문헌 신청
[학술지(정기간행물)] - Attele AS / 2002 / Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component / Diabetes 51 : 1851 ~ 1858
[학술지(정기간행물)] - Dey L / 2003 / Anti-hyperglycemic effects of ginseng: comparison between root and berry / Phytomedicine 10 : 600 ~ 605
[학술지(정기간행물)] - Xie J / 2002 / Ginseng berry reduces blood glucose and body weight in db/db mice / Phytomedicine 9 : 254 ~ 258
[학술지(정기간행물)] - 이미라 / 2013 / Anti-obesity effects of black ginseng extract in high fat diet-fed mice / Journal of Ginseng Research 37 (3) : 308 ~ 314
[학술지(정기간행물)] - Liu R / 2010 / Anti-obesity effects of protopanaxdiol types of ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet / Fitoterapia 81 : 1079 ~ 1087
[학술지(정기간행물)] - Dey L / 2003 / Anti-hyperglycemic effects of ginseng: comparison between root and berry / Phytomedicine 10 : 600 ~ 605
[학술지(정기간행물)] - Xie J / 2002 / Ginseng berry reduces blood glucose and body weight in db/db mice / Phytomedicine 9 : 254 ~ 258
[학술지(정기간행물)] - 이미라 / 2013 / Anti-obesity effects of black ginseng extract in high fat diet-fed mice / Journal of Ginseng Research 37 (3) : 308 ~ 314
[학술지(정기간행물)] - Liu R / 2010 / Anti-obesity effects of protopanaxdiol types of ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet / Fitoterapia 81 : 1079 ~ 1087
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UCI(KEPA) : I410-ECN-0101-2018-524-003161180