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Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation
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Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation

논문 기본 정보

자료유형
학술저널
저자정보
Juewon Kim (AmorePacific Corporation) Si Young Cho (AmorePacific Corporation) Su Hwan Kim (AmorePacific Corporation) Donghyun Cho (AmorePacific Corporation) Sunmi Kim (AmorePacific Corporation) Chan-Woong Park (AmorePacific Corporation) Takahiko Shimizu (Chiba University) Jae Youl Cho (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.41 No.3 KCI Candidated Journals SCIE
발행연도
2017.7
수록면
277 - 283 (7page)

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연구결과
Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation
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초록· 키워드

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Background: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging.
Methods: The human melanoma MNT1 cell line was treated with ginseng root extract, ginseng berry extract, or syringaresinol. Then, the cells were analyzed using a melanin assay, and the tyrosinase activity was estimated. The Caenorhabditis elegans wild type N2 strain was used for the life span assay to analyze the antiaging effects of the samples. A lipofuscin fluorescence assay was performed during 10 passages with the syringaresinol treatment.
Results: A 7-d treatment with ginseng berry extract reduced melanin accumulation and tyrosinase activity more than ginseng root extract. These results may be due to the active compound of the ginseng berry, syringaresinol. The antimelanogenic activity was strongly coordinated with the activation of the longevity gene foxo3a. Moreover, the ginseng berry extract had more potent antiaging effects, caused a life span extension, and reduced lipofuscin accumulation.
Conclusion: Taken together, our results suggest that these antimelanogenic effects and antiaging effects of ginseng berry mediate the activation of antioxidationeFoxO3a signaling.

목차

ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References

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