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자료유형
학술저널
저자정보
Cuicui Chen (Guangzhou Youdi Biotechnology Company) Xiaozhu Liu (Guizhou Institute of Industry) Yinfeng Li (Guizhou Institute of Industry) Huankun Liang (Guangzhou Youdi Biotechnology Company) Kangyan Li (Guangzhou Youdi Biotechnology Company) Jiali Li (Guangzhou Youdi Biotechnology Company) Chengwu Cheng (Guangzhou Youdi Biotechnology Company) Xianpan Liu (Guangzhou Youdi Biotechnology Company) Shuhai Zhong (Guangzhou Youdi Biotechnology Company) Laiqing Li (Guangzhou Youdi Biotechnology Company) Yan Wang (Shandong Medicine Technician College)
저널정보
대한약침학회 Journal of Acupuncture & Meridian Studies Journal of Acupuncture & Meridian Studies Vol.10 No.4
발행연도
2017.1
수록면
252 - 260 (9page)

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Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1b, TNF-a) mRNA compared with DNCB treatment. Acupuncture treatment also inhibited nuclear factor-kB p65, phosphorylation of IkBa, and phosphorylation of occludin proteins expression. Furthermore, it could improve the expression of epidermal growth factor in both mRNA and protein levels. These results suggest that acupuncture, as an alternative therapy treatment for its no significant side effects, was effective in alleviating ACD by reducing proinflammatory cytokines and changing proteins’ expression.

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